PMID- 28512425
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1663-2699 (Print)
IS  - 1663-2699 (Electronic)
IS  - 1663-2699 (Linking)
VI  - 8
IP  - 1
DP  - 2017 Jan-Apr
TI  - Long-Term Follow-Up of Polypoidal Choroidal Vasculopathy Secondary to Angioid 
      Streaks Treated by Intravitreal Aflibercept and Ranibizumab.
PG  - 221-231
LID - 10.1159/000468144 [doi]
AB  - PURPOSE: Angioid streaks (AS) are dehiscences in Bruch's membrane that may be 
      idiopathic or associated with numerous systemic illnesses. Polypoidal choroidal 
      vasculopathy (PCV) is an underdiagnosed exudative chorioretinopathy often 
      characterised by serosanguineous detachments of the pigmented epithelium. The use 
      of the anti-VEGF agents ranibizumab and aflibercept in the management of PCV 
      secondary to AS has not been previously documented. We report 3 patients with 
      active PCV secondary to AS, 1 of which had a family history of PCV secondary to 
      AS, not previously reported in the literature. All patients were symptomatic and 
      treated with intravitreal anti-VEGF therapy with and without combination 
      photodynamic therapy (PDT). METHODS: This is a long-term retrospective case 
      review of 3 eyes of 3 patients with AS and clinical features of PCV. The patients 
      were examined using fundoscopy, spectral domain optical coherence tomography, 
      fluorescein angiography, and indocyanine green angiography. All patients were 
      managed with intravitreal anti-VEGF using a treat-and-extend protocol according 
      to specific retreatment criteria. One patient had 1 session of PDT in combination 
      with anti-VEGF injections. RESULTS: The mean follow-up time in all patients was 4 
      years. In all 3 cases, the treatment resulted in improved visual acuity and 
      regression of active PCV lesions with a longer duration between injections. 
      CONCLUSION: The treat-and-extend protocol with intravitreal aflibercept or 
      ranibizumab with or without PDT is effective and safe for PCV secondary to AS.
FAU - Wong, James G
AU  - Wong JG
AD  - Strathfield Retina Clinic, Sydney, NSW, Australia.
FAU - Qian, Katherine Yu
AU  - Qian KY
AD  - Strathfield Retina Clinic, Sydney, NSW, Australia.
LA  - eng
PT  - Case Reports
DEP - 20170410
PL  - Switzerland
TA  - Case Rep Ophthalmol
JT  - Case reports in ophthalmology
JID - 101532006
PMC - PMC5422748
OTO - NOTNLM
OT  - Aflibercept
OT  - Angioid streaks
OT  - Choroidal neovascularisation
OT  - Choroidal nevus
OT  - Fluorescein angiography
OT  - Indocyanine green angiography
OT  - Optical coherence tomography
OT  - Polypoidal choroidal vasculopathy
OT  - Ranibizumab
OT  - Subretinal fluid
EDAT- 2017/05/18 06:00
MHDA- 2017/05/18 06:01
PMCR- 2017/04/10
CRDT- 2017/05/18 06:00
PHST- 2017/01/23 00:00 [received]
PHST- 2017/02/28 00:00 [revised]
PHST- 2017/05/18 06:00 [entrez]
PHST- 2017/05/18 06:00 [pubmed]
PHST- 2017/05/18 06:01 [medline]
PHST- 2017/04/10 00:00 [pmc-release]
AID - cop-0008-0221 [pii]
AID - 10.1159/000468144 [doi]
PST - epublish
SO  - Case Rep Ophthalmol. 2017 Apr 10;8(1):221-231. doi: 10.1159/000468144. 
      eCollection 2017 Jan-Apr.