PMID- 28512561
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2035-3006 (Print)
IS  - 2035-3006 (Electronic)
IS  - 2035-3006 (Linking)
VI  - 9
IP  - 1
DP  - 2017
TI  - Bone Marrow Homing and Engraftment Defects of Human Hematopoietic Stem and 
      Progenitor Cells.
PG  - e2017032
LID - 10.4084/MJHID.2017.032 [doi]
LID - e2017032
AB  - Homing of hematopoietic stem cells (HSC) to their microenvironment niches in the 
      bone marrow is a complex process with a critical role in repopulation of the bone 
      marrow after transplantation. This active process allows for migration of HSC 
      from peripheral blood and their successful anchoring in bone marrow before 
      proliferation. The process of engraftment starts with the onset of proliferation 
      and must, therefore, be functionally dissociated from the former process. In this 
      overview, we analyze the characteristics of stem cells (SCs) with particular 
      emphasis on their plasticity and ability to find their way home to the bone 
      marrow. We also address the problem of graft failure which remains a significant 
      contributor to morbidity and mortality after allogeneic hematopoietic stem cell 
      transplantation (HSCT). Within this context, we discuss non-malignant and 
      malignant hematological disorders treated with reduced-intensity conditioning 
      regimens or grafts from human leukocyte antigen (HLA)-mismatched donors.
FAU - Caocci, Giovanni
AU  - Caocci G
AD  - Hematology Unit, Bone Marrow Transplant Center, R. Binaghi Hospital, Department 
      of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
FAU - Greco, Marianna
AU  - Greco M
AD  - Hematology Unit, Bone Marrow Transplant Center, R. Binaghi Hospital, Department 
      of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
FAU - La Nasa, Giorgio
AU  - La Nasa G
AD  - Hematology Unit, Bone Marrow Transplant Center, R. Binaghi Hospital, Department 
      of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170419
PL  - Italy
TA  - Mediterr J Hematol Infect Dis
JT  - Mediterranean journal of hematology and infectious diseases
JID - 101530512
PMC - PMC5419183
OTO - NOTNLM
OT  - Engraftment
OT  - Homing
OT  - Stem cells
COIS- Competing interests: The authors have declared that no competing interests exist.
EDAT- 2017/05/18 06:00
MHDA- 2017/05/18 06:01
PMCR- 2017/01/01
CRDT- 2017/05/18 06:00
PHST- 2017/01/14 00:00 [received]
PHST- 2017/03/18 00:00 [accepted]
PHST- 2017/05/18 06:00 [entrez]
PHST- 2017/05/18 06:00 [pubmed]
PHST- 2017/05/18 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - mjhid-9-1-e2017032 [pii]
AID - 10.4084/MJHID.2017.032 [doi]
PST - epublish
SO  - Mediterr J Hematol Infect Dis. 2017 Apr 19;9(1):e2017032. doi: 
      10.4084/MJHID.2017.032. eCollection 2017.