PMID- 28516314
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 33
IP  - 11
DP  - 2017 Nov
TI  - Harmonic subtraction for evaluating right ventricle ejection fraction from planar 
      equilibrium radionuclide angiography.
PG  - 1857-1862
LID - 10.1007/s10554-017-1164-5 [doi]
AB  - We report an initial investigation of a subtraction-based method to estimate 
      right ventricle ejection fraction (RVEF) from ECG-gated planar equilibrium 
      radionuclide angiography (ERNA) data. Twenty-six consecutive patients referred 
      for scintigraphic evaluation of cardiac function prior to chemotherapy had 
      ECG-gated first-pass (FP) imaging and ERNA imaging performed following the same 
      radiotracer injection. RVEF was computed from FP images (RVEF(FP)) and separately 
      from ERNA images (RVEF(ERNA)). Standard methods for computing ejection fractions 
      were used to obtain RVEF(FP) values. RVEF(ERNA) values were obtained using 
      harmonic subtraction of the left ventricular contribution from a biventricular 
      region of interest contoured on the equilibrium images acquired in the shallow 
      right anterior oblique projection. Clinically acquired chest CT data were used to 
      derive information regarding the relative position of the left and right 
      ventricle and about the presence of pulmonary artery enlargement. Computation of 
      RVEF(ERNA) was successful for each of the 26 patients. Computation of RVEF(FP) 
      failed for four patients. For the 22 patients for which RVEF was computed using 
      both methods, the average RVEF(FP) was 49% and the average RVEF(ERNA) was 51%, 
      with coefficients of variation of 11 and 7.5%, respectively. Low RVEF(ERNA) 
      values were associated with pulmonary artery dilation. Estimation of RVEF(ERNA), 
      using a harmonic subtraction-based method of computation is clinically feasible 
      and accurate in the patient population studied. The results support further 
      investigation in patients with frank heart failure.
FAU - Bonta, Dacian V
AU  - Bonta DV
AUID- ORCID: 0000-0003-3052-6874
AD  - VAMC Atlanta, Nuclear Medicine Service (115), Veterans Affairs Medical 
      Center-Atlanta, 1670 Clairmont Rd., Decatur, GA, 30033, USA. dvbonta@yahoo.com.
AD  - Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd., 
      Atlanta, 30322, GA, USA. dvbonta@yahoo.com.
FAU - Aarsvold, John N
AU  - Aarsvold JN
AD  - VAMC Atlanta, Nuclear Medicine Service (115), Veterans Affairs Medical 
      Center-Atlanta, 1670 Clairmont Rd., Decatur, GA, 30033, USA.
AD  - Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd., 
      Atlanta, 30322, GA, USA.
FAU - Grant, Sandra F
AU  - Grant SF
AD  - VAMC Atlanta, Nuclear Medicine Service (115), Veterans Affairs Medical 
      Center-Atlanta, 1670 Clairmont Rd., Decatur, GA, 30033, USA.
FAU - Alazraki, Naomi P
AU  - Alazraki NP
AD  - VAMC Atlanta, Nuclear Medicine Service (115), Veterans Affairs Medical 
      Center-Atlanta, 1670 Clairmont Rd., Decatur, GA, 30033, USA.
AD  - Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd., 
      Atlanta, 30322, GA, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170517
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Radiopharmaceuticals)
RN  - A0730CX801 (Sodium Pertechnetate Tc 99m)
SB  - IM
MH  - Cardiac-Gated Imaging Techniques
MH  - Computed Tomography Angiography
MH  - Electrocardiography
MH  - Female
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnostic imaging/physiopathology
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Linear Models
MH  - Male
MH  - Predictive Value of Tests
MH  - Radionuclide Angiography/*methods
MH  - Radiopharmaceuticals/*administration & dosage
MH  - Retrospective Studies
MH  - Sodium Pertechnetate Tc 99m/*administration & dosage
MH  - *Stroke Volume
MH  - Ventricular Dysfunction, Right/*diagnostic imaging/physiopathology
MH  - Ventricular Function, Left
MH  - *Ventricular Function, Right
OTO - NOTNLM
OT  - Equilibrium radionuclide angiography
OT  - Harmonic subtraction
OT  - Right ventricle ejection fraction
EDAT- 2017/05/19 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/05/19 06:00
PHST- 2017/01/31 00:00 [received]
PHST- 2017/05/08 00:00 [accepted]
PHST- 2017/05/19 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2017/05/19 06:00 [entrez]
AID - 10.1007/s10554-017-1164-5 [pii]
AID - 10.1007/s10554-017-1164-5 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2017 Nov;33(11):1857-1862. doi: 
      10.1007/s10554-017-1164-5. Epub 2017 May 17.