PMID- 28517847
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2473-4209 (Electronic)
IS  - 0094-2405 (Linking)
VI  - 39
IP  - 6Part12
DP  - 2012 Jun
TI  - SU-E-T-204: A Prototype of Dose-Guided Radiation Therapy.
PG  - 3750
LID - 10.1118/1.4735264 [doi]
AB  - PURPOSE: With the advancement in dosimetric devices and the development of dose 
      reconstruction algorithm, the implementation of dose-guided radiation therapy 
      (DGRT) is feasible. In order for DGRT to be performed clinically, a prototype of 
      DGRT was developed in this study. METHODS: The prototype adopted a strategy for 
      DGRT that adjusted the treatment plan for future fractions to compensate for 
      dosimetric errors from past fractions, which included four main functional 
      modules: management of patient plan information, dose reconstruction, dose 
      evaluation, plan adjustment. we developed our dose reconstruction procedure, 
      including the dosimetric calibration of the portal image acquired using 
      electronic portal image device (EPID) during treatment and three-dimensional (3D) 
      patient dose reconstruction based on Monte Carlo Finite-size pencil beam (MCFSPB) 
      model and Conjugate-gradient (CG) algorithm developed by FDS Team 
      (www.fds.org.cn). The dose evaluation tools including 3D Gamma analysis and 
      dose-volume-histogram (DVH) analysis were also available which were used to 
      compare the reconstruction dose with the planning dose. Finally we re-optimizing 
      the treatment plan according to the information provided by dose evaluation. 
      RESULTS: In order to validate the availability of the workstation prototype, lots 
      of experiments were carried out based on head phantom. The result showed that 
      disagreement between the reconstructed dose and the planning dose (calculated by 
      the Accurate Radiotherapy System (ARTS) developed by FDS Team) was observed by 
      the DGRT prototype when there existed position error for head phantom or the 
      accelerator delivery was not accurate. CONCLUSIONS: An effective prototype for 
      DGRT has been developed. With these techniques, the clinical implementation of 
      DGRT is possible in the near future. Supported by the National Natural Science 
      Foundation under grant No.30900386 and the National Science Foundation of Anhui 
      Province (Nos.090413095 and 111040606Q55).
CI  - (c) 2012 American Association of Physicists in Medicine.
FAU - Ren, Qiang
AU  - Ren Q
AD  - Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, 
      Hefei, Anhui, China.
AD  - Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, China.
AD  - School of Nuclear Science and Technology, University of Science and Technology of 
      China, Hefei, Anhui, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy, Anhui Province, 
      Hefei, Anhui, China.
FAU - Li, Gui
AU  - Li G
AD  - Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, 
      Hefei, Anhui, China.
AD  - Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, China.
AD  - School of Nuclear Science and Technology, University of Science and Technology of 
      China, Hefei, Anhui, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy, Anhui Province, 
      Hefei, Anhui, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, 
      Hefei, Anhui, China.
AD  - Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, China.
AD  - School of Nuclear Science and Technology, University of Science and Technology of 
      China, Hefei, Anhui, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy, Anhui Province, 
      Hefei, Anhui, China.
FAU - Wu, Yican
AU  - Wu Y
AD  - Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, 
      Hefei, Anhui, China.
AD  - Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, China.
AD  - School of Nuclear Science and Technology, University of Science and Technology of 
      China, Hefei, Anhui, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy, Anhui Province, 
      Hefei, Anhui, China.
CN  - FDS Team
AD  - Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, 
      Hefei, Anhui, China.
AD  - Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, China.
AD  - School of Nuclear Science and Technology, University of Science and Technology of 
      China, Hefei, Anhui, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy, Anhui Province, 
      Hefei, Anhui, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
OTO - NOTNLM
OT  - Calibration
OT  - Dosimetry
OT  - Image guided radiation therapy
OT  - Image reconstruction
OT  - Medical image reconstruction
OT  - Medical imaging
OT  - Monte Carlo algorithms
OT  - Monte Carlo methods
OT  - Radiation therapy
OT  - Radiation treatment
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2017/05/19 06:00
PHST- 2017/05/19 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - 10.1118/1.4735264 [doi]
PST - ppublish
SO  - Med Phys. 2012 Jun;39(6Part12):3750. doi: 10.1118/1.4735264.