PMID- 28518240
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2473-4209 (Electronic)
IS  - 0094-2405 (Linking)
VI  - 39
IP  - 6Part21
DP  - 2012 Jun
TI  - MO-F-BRCD-01: Stereotactic Body Radiation Therapy: Updates on Clinical, 
      Biological, and Physics/QA:SBRT (Part 1): Biological and Clinical Updates.
PG  - 3873
LID - 10.1118/1.4735812 [doi]
AB  - Stereotactic Body Radiation Therapy (SBRT) is an important form of cancer therapy 
      with increasingly broad application across a spectrum of tumor types in primary 
      and metastatic settings. In this presentation the radiation biology, clinical 
      experience from various trials, and cautionary updates on normal tissue 
      tolerances will be presented. The effective radiobiology of SBRT and 
      hypofractionated courses of therapy has become more evident with the increasing 
      reports of retrospective clinical outcomes and prospective clinical trial 
      results. Current open multi-institutional national cooperative trials will be 
      reviewed. Accumulating clinical experiences are yielding new insights into 
      practical aspects of tumor and normal tissue responses to high dose per fraction 
      treatment. Indeed, SBRT has produced profound tumoricidal and ablative effects, 
      however there is potential for grave toxicity and this demands that clinicians be 
      knowledgeable regarding normal tissue tolerances for various hypofractionated 
      courses. As a final note, the technology associated with SBRT has evolved 
      remarkably in the last decade, and procedures that originally required hours to 
      plan, with cumbersome quality assurance methods, arduous set-up times, and long 
      protracted deliveries can now be performed in ever shorter time periods. Given 
      these technology improvements and recognizing the great palliative potential of 
      hypofractionated radiation therapy to relieve cancer symptoms quickly and 
      efficiently, a new strategy to deliver SBRT in a single session called STAT RAD 
      is presented for discussion.
CI  - (c) 2012 American Association of Physicists in Medicine.
FAU - Read, P
AU  - Read P
AD  - University of Virginia, Charlottesville, VA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
OTO - NOTNLM
OT  - Cancer
OT  - Dosimetry
OT  - Drug delivery
OT  - Quality assurance
OT  - Radiation therapy
OT  - Radiosurgery
OT  - Tissue engineering
OT  - Tissues
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2017/05/19 06:00
PHST- 2017/05/19 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - 10.1118/1.4735812 [doi]
PST - ppublish
SO  - Med Phys. 2012 Jun;39(6Part21):3873. doi: 10.1118/1.4735812.