PMID- 28520222
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1520-6300 (Electronic)
IS  - 1042-0533 (Linking)
VI  - 2
IP  - 4
DP  - 1990
TI  - High prevalence of human T-lymphotropic virus type I infection in isolated 
      populations of the Western Pacific region confirmed by Western immunoblot.
PG  - 439-447
LID - 10.1002/ajhb.1310020411 [doi]
AB  - High prevalences of antibodies against human T-lymphotropic virus type I 
      (HTLV-I), as confirmed by Western immunoblot, were found in several remote 
      indigenous populations of the Solomon Islands and Vanuatu and in some isolated 
      populations of New Guinea that had no contact with Japanese or Africans and 
      little contact with Caucasians prior to our bleedings. By contrast, zero or very 
      low prevalences of HTLV-I infection were found in Guamanians and Carolinians, 
      despite more than 30 years of intense contact with the Japanese. A total of 1,601 
      sera, collected between 1963 and 1981 from 21 population groups in the Western 
      Pacific, was tested by enzyme-linked immunosorbent assay (ELISA) for IgG 
      antibodies to HTLV-I. By ELISA, prevalences of antibodies against HTLV-I ranged 
      from zero to 50%. Seropositivity could be confirmed in only 12.5% of 48 
      ELISA-positive sera selected for testing by Western immunoblot. However, the 
      confirmed HTLV-I seroprevalences in some Melanesian populations were still as 
      high as those found in HTLV-I-endemic regions, such as southwestern Japan and the 
      Caribbean basin. HTLV-I prevalences were similar among males and females, and 
      acquisition of antibodies increased with age. Our data indicate that infections 
      with HTLV-I or a related retrovirus have been widespread in the southwestern 
      Pacific for over 25 year in populations with minimal outside contact, while some 
      populations which had extensive Japanese contact have no evidence of infection. 
      Furthermore, based on the high frequency of indeterminate Western immunoblots, we 
      conclude that in Melanesia this may represent either incomplete specific 
      reactivity to HTLV-I or the existence of an antigenic variant of HTLV-I, distinct 
      from prototype Japanese, American, and European HTLV-I strains.
CI  - Copyright (c) 1990 Wiley-Liss, Inc., A Wiley Company.
FAU - Garruto, R M
AU  - Garruto RM
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Slover, M
AU  - Slover M
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Yanagihara, R
AU  - Yanagihara R
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Mora, C A
AU  - Mora CA
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Alexander, S S
AU  - Alexander SS
AD  - Biotech Research Laboratories, Inc., Rockville, Maryland.
FAU - Asher, D M
AU  - Asher DM
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Rodgers-Johnson, P
AU  - Rodgers-Johnson P
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Gajdusek, D C
AU  - Gajdusek DC
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Hum Biol
JT  - American journal of human biology : the official journal of the Human Biology 
      Council
JID - 8915029
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 2017/05/19 06:00
PHST- 1989/12/02 00:00 [received]
PHST- 1990/03/23 00:00 [accepted]
PHST- 2017/05/19 06:00 [entrez]
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
AID - 10.1002/ajhb.1310020411 [doi]
PST - ppublish
SO  - Am J Hum Biol. 1990;2(4):439-447. doi: 10.1002/ajhb.1310020411.