PMID- 28521326
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20180612
IS  - 1423-002X (Electronic)
IS  - 0378-7346 (Linking)
VI  - 82
IP  - 5
DP  - 2017
TI  - The Yield of Abdominal Ultrasound in the Evaluation of Elevated Liver Enzymes 
      during the Second and the Third Trimester of Pregnancy.
PG  - 517-520
LID - 10.1159/000453612 [doi]
AB  - AIMS: To determine the clinical yield of abdominal ultrasound in the evaluation 
      of elevated liver enzymes (ELEs) in the second and the third trimester of 
      pregnancy. METHODS: A retrospective cohort study including all pregnant women 
      admitted to a single tertiary care center was conducted between April 2011 and 
      January 2015 with ELE. Inclusion criteria included gestational age above 24 weeks 
      and ELEs, abdominal ultrasound report, and live fetus. Exclusion criteria 
      included known maternal liver disease, structural or chromosomal fetal anomalies, 
      and positive serology for viral hepatitis. All patients underwent abdominal 
      ultrasound. A significant finding of this study led to a change in treatment. 
      RESULTS: One hundred and twenty patients (41.8%) met inclusion criteria: 93 
      (77.5%) had a normal scan and 27 (22.5%) had abnormal findings. Significant 
      ultrasound findings were found only in 2 (1.6%) patients: gallstones in the 
      common bile duct and suspected autoimmune hepatitis. There were no significant 
      differences between patients with and without ultrasound findings in the rate of 
      cholestasis of pregnancy, preeclampsia, chronic hypertension, and gestation 
      diabetes. CONCLUSION: Abdominal ultrasound examination in this population has a 
      low clinical yield. The decision to perform an abdominal ultrasound must be 
      individualized based on the obstetric history, clinical findings, and the level 
      of liver enzymes.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Mohr-Sasson, Aya
AU  - Mohr-Sasson A
AD  - Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, 
      Israel.
FAU - Schiff, Eyal
AU  - Schiff E
FAU - Suday, Ramy Rahamim
AU  - Suday RR
FAU - Hayman, Zehava
AU  - Hayman Z
FAU - Kleinbaum, Yeruham
AU  - Kleinbaum Y
FAU - Kalter-Farber, Anat
AU  - Kalter-Farber A
FAU - Mashiach, Roy
AU  - Mashiach R
FAU - Yinon, Yoav
AU  - Yinon Y
FAU - Dulitzki, Moti
AU  - Dulitzki M
FAU - Sivan, Eyal
AU  - Sivan E
FAU - Mazaki-Tovi, Shali
AU  - Mazaki-Tovi S
LA  - eng
PT  - Journal Article
DEP - 20170519
PL  - Switzerland
TA  - Gynecol Obstet Invest
JT  - Gynecologic and obstetric investigation
JID - 7900587
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Aspartate Aminotransferases/blood
MH  - Female
MH  - Gallstones/complications/diagnostic imaging
MH  - Gestational Age
MH  - Hepatitis, Autoimmune/complications/diagnostic imaging
MH  - Humans
MH  - Liver/*diagnostic imaging/enzymology
MH  - Liver Diseases/*complications/diagnostic imaging/enzymology
MH  - Pre-Eclampsia
MH  - Pregnancy
MH  - Pregnancy Complications/*diagnostic imaging
MH  - Pregnancy Trimester, Second
MH  - Pregnancy Trimester, Third
MH  - Retrospective Studies
MH  - Ultrasonography
MH  - Ultrasonography, Prenatal
OTO - NOTNLM
OT  - Abdominal ultrasound
OT  - Elevated liver enzymes
OT  - Intrahepatic cholestasis of pregnancy
OT  - Preeclampsia
EDAT- 2017/05/19 06:00
MHDA- 2018/06/13 06:00
CRDT- 2017/05/19 06:00
PHST- 2016/04/19 00:00 [received]
PHST- 2016/11/21 00:00 [accepted]
PHST- 2017/05/19 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
PHST- 2017/05/19 06:00 [entrez]
AID - 000453612 [pii]
AID - 10.1159/000453612 [doi]
PST - ppublish
SO  - Gynecol Obstet Invest. 2017;82(5):517-520. doi: 10.1159/000453612. Epub 2017 May 
      19.