PMID- 28521406
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 13
IP  - 5
DP  - 2017 May
TI  - High-concentration glucose enhances invasion in invasive ductal breast carcinoma 
      by promoting Glut1/MMP2/MMP9 axis expression.
PG  - 2989-2995
LID - 10.3892/ol.2017.5843 [doi]
AB  - Type 2 diabetes mellitus (T2DM) has been considered to be a risk factor for 
      numerous human cancers. Hyperglycemia is one of the most direct internal 
      environmental changes for patients with T2DM. Increasing evidence reveals that a 
      high concentration of glucose can promote tumor progression, while its role for 
      migration and invasion of invasive ductal breast carcinoma (IDBC) cells remains 
      unclear. In the present study, it was demonstrated that IDBC patients with T2DM 
      suffered an increased tumor size and more frequent lymphatic and distant 
      metastasis compared with those without T2DM (P<0.05). MCF-7 breast carcinoma 
      cells, which were cultured in a high glucose concentration medium (25.00 mM), 
      exhibited increased invasion (P<0.05). In addition, the expression of glucose 
      transporters (Gluts), matrix metalloproteinase 2 (MMP2) and matrix 
      metalloproteinase 9 (MMP9) in IDBC tissues with T2DM was significantly higher 
      compared to those without T2DM. Downregulation of glucose transporter 1 (Glut1) 
      by small interfering RNA may markedly suppress MCF-7 cell invasion as well as the 
      expression of MMP2 and MMP9. These results suggest that T2DM can affect the 
      malignant features of tumors in IDBC. The high glucose concentration in the tumor 
      microenvironment may enhance IDBC invasion via upregulating Glut1/MMP2/MMP9 axis 
      expression.
FAU - Sun, Xian-Fu
AU  - Sun XF
AD  - Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. 
      China.
FAU - Shao, Ying-Bo
AU  - Shao YB
AD  - Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. 
      China.
FAU - Liu, Ming-Ge
AU  - Liu MG
AD  - Department of Pathology, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. 
      China.
FAU - Chen, Qi
AU  - Chen Q
AD  - Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. 
      China.
FAU - Liu, Zhao-Jun
AU  - Liu ZJ
AD  - Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. 
      China.
FAU - Xu, Bin
AU  - Xu B
AD  - Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. 
      China.
FAU - Luo, Su-Xia
AU  - Luo SX
AD  - Department of Medical Oncology, Henan Cancer Hospital, Zhengzhou, Henan 450008, 
      P.R. China.
FAU - Liu, Hui
AU  - Liu H
AD  - Department of Galactophore, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. 
      China.
LA  - eng
PT  - Journal Article
DEP - 20170313
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5431328
OTO - NOTNLM
OT  - Glut1
OT  - MMP2
OT  - MMP9
OT  - invasion
OT  - invasive ductal breast carcinoma
OT  - type 2 diabetes mellitus
EDAT- 2017/05/20 06:00
MHDA- 2017/05/20 06:01
PMCR- 2017/03/13
CRDT- 2017/05/20 06:00
PHST- 2015/07/08 00:00 [received]
PHST- 2016/10/13 00:00 [accepted]
PHST- 2017/05/20 06:00 [entrez]
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2017/05/20 06:01 [medline]
PHST- 2017/03/13 00:00 [pmc-release]
AID - OL-0-0-5843 [pii]
AID - 10.3892/ol.2017.5843 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 May;13(5):2989-2995. doi: 10.3892/ol.2017.5843. Epub 2017 Mar 
      13.