PMID- 28521437
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 13
IP  - 5
DP  - 2017 May
TI  - IL-35 expression is increased in laryngeal squamous cell carcinoma and in the 
      peripheral blood of patients.
PG  - 3303-3308
LID - 10.3892/ol.2017.5858 [doi]
AB  - Interleukin-35 (IL-35) has been proposed as a novel immune-suppressing cytokine. 
      However, the function of IL-35 in malignant diseases is yet to be elucidated. The 
      present study investigated IL-35 expression levels in laryngeal squamous cell 
      carcinoma (LSCC) tissues and the peripheral blood of patients to explore the 
      potential involvement of IL-35 in LSCC progression. In the present study, IL-35 
      expression levels in tissues and peripheral blood were analyzed by reverse 
      transcription-quantitative polymerase chain reaction and an enzyme-linked 
      immunosorbent assay. The association between IL-35 expression levels and clinical 
      characteristics was also evaluated. The present results demonstrated that IL-35 
      expression in tumor tissues was significantly higher than in adjacent normal 
      tissues, and a significant association between IL-35 expression levels in tissues 
      and the tumor site was detected. Furthermore, the expression of IL-35 in the 
      peripheral blood of patients was significantly decreased subsequent to tumor 
      resection. No correlation between peripheral blood IL-35 expression and clinical 
      characteristics was detected. In conclusion, the present study demonstrated that 
      IL-35 is highly expressed in LSCC tissues and in the peripheral blood of patients 
      with LSCC. There was a notable, significant reduction of peripheral blood IL-35 
      expression following surgical resection of tumors. These results may be useful 
      for diagnostic or therapeutic purposes in patients with LSCC.
FAU - Wu, Wei
AU  - Wu W
AD  - Eye Center, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 
      Hangzhou, Zhejiang 310009, P.R. China.
FAU - Jiang, Hua
AU  - Jiang H
AD  - Department of Otolaryngology, 2nd Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Otolaryngology, 2nd Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.
FAU - Yan, Mao-Xiao
AU  - Yan MX
AD  - Department of Otolaryngology, 2nd Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170314
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5431269
OTO - NOTNLM
OT  - Epstein Barr virus-induced gene
OT  - interleukin-12 p35
OT  - interleukin-35
OT  - laryngeal squamous cell carcinoma
OT  - peripheral blood
EDAT- 2017/05/20 06:00
MHDA- 2017/05/20 06:01
PMCR- 2017/03/14
CRDT- 2017/05/20 06:00
PHST- 2015/12/02 00:00 [received]
PHST- 2017/02/03 00:00 [accepted]
PHST- 2017/05/20 06:00 [entrez]
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2017/05/20 06:01 [medline]
PHST- 2017/03/14 00:00 [pmc-release]
AID - OL-0-0-5858 [pii]
AID - 10.3892/ol.2017.5858 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 May;13(5):3303-3308. doi: 10.3892/ol.2017.5858. Epub 2017 Mar 
      14.