PMID- 28521466
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 13
IP  - 5
DP  - 2017 May
TI  - Extranodal marginal zone lymphoma of the uterine cervix with concomitant copy 
      number gains of the MALT1 and BCL2 genes: A case report.
PG  - 3641-3645
LID - 10.3892/ol.2017.5944 [doi]
AB  - Extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissue 
      (MALT) of the uterus is rare, and the etiology, pathophysiology and cytogenetic 
      features remain unknown at present. The present study reports a case of a 
      71-year-old female with EMZL of the uterine cervix that was 80 mm in diameter and 
      invaded directly into the rectal serosa. Complete remission was successfully 
      induced by 6 courses of immunochemotherapy with rituximab plus cyclophosphamide, 
      doxorubicin, vincristine and prednisolone. Although the metaphase spread of the 
      tumor cells was unavailable for whole cytogenetic analysis, fluorescence in situ 
      hybridization (FISH) detected triple signals for MALT1 and B-cell lymphoma 2, 
      located at chromosome 18q21, and the centromere of chromosome 18, which was 
      suggestive of trisomy 18, and in combination with previous studies, suggested a 
      possible association between trisomy 18 and the large tumor at initial 
      presentation in the present patient. In addition, FISH examination detected 
      immunoglobulin heavy chain gene rearrangement, although the translocation partner 
      was unconfirmed. A total of 18 previously-studied patients with EMZL of the 
      uterus, including that of the present study, were reviewed with respect to their 
      clinical features and treatment and cytogenetic abnormality. In the evaluation of 
      the English scientific literature, this is the first reported patient with EMZL 
      of the uterus with partly determined cytogenetic abnormalities.
FAU - Takimoto, Tomoko
AU  - Takimoto T
AD  - Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, 
      Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Maegawa, Saori
AU  - Maegawa S
AD  - Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, 
      Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Tatsumi, Hiroshi
AU  - Tatsumi H
AD  - Department of Obstetrics and Gynecology, Kyoto Prefectural University of 
      Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Nagoshi, Hisao
AU  - Nagoshi H
AD  - Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, 
      Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Chinen, Yoshiaki
AU  - Chinen Y
AD  - Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, 
      Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Shimura, Yuji
AU  - Shimura Y
AD  - Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, 
      Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Kobayashi, Tsutomu
AU  - Kobayashi T
AD  - Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, 
      Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Horiike, Shigeo
AU  - Horiike S
AD  - Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, 
      Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Nakamura, Shigeo
AU  - Nakamura S
AD  - Department of Pathology and Laboratory Medicine, Nagoya University Hospital, 
      Nagoya 466-8550, Japan.
FAU - Kitawaki, Jo
AU  - Kitawaki J
AD  - Department of Obstetrics and Gynecology, Kyoto Prefectural University of 
      Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Kuroda, Junya
AU  - Kuroda J
AD  - Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, 
      Graduate School of Medical Science, Kyoto 602-8566, Japan.
FAU - Taniwaki, Masafumi
AU  - Taniwaki M
AD  - Department of Hematology and Oncology, Kyoto Prefectural University of Medicine, 
      Graduate School of Medical Science, Kyoto 602-8566, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170329
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5431356
OTO - NOTNLM
OT  - FISH
OT  - extranodal marginal zone lymphoma
OT  - trisomy 18
OT  - uterus
EDAT- 2017/05/20 06:00
MHDA- 2017/05/20 06:01
PMCR- 2017/03/29
CRDT- 2017/05/20 06:00
PHST- 2016/02/18 00:00 [received]
PHST- 2017/01/31 00:00 [accepted]
PHST- 2017/05/20 06:00 [entrez]
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2017/05/20 06:01 [medline]
PHST- 2017/03/29 00:00 [pmc-release]
AID - OL-0-0-5944 [pii]
AID - 10.3892/ol.2017.5944 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 May;13(5):3641-3645. doi: 10.3892/ol.2017.5944. Epub 2017 Mar 
      29.