PMID- 28523032
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240326
IS  - 1682-024X (Print)
IS  - 1681-715X (Electronic)
IS  - 1681-715X (Linking)
VI  - 33
IP  - 2
DP  - 2017 Mar-Apr
TI  - Serum Uric Acid level in the severity of Congestive Heart Failure (CHF).
PG  - 330-334
LID - 10.12669/pjms.332.11779 [doi]
AB  - BACKGROUND AND OBJECTIVE: It has been observed that in a clinical condition like 
      hypoxemia there is an increase in the serum Uric acid level. The objective of our 
      study was to find out the relationship between serum uric acid levels in the 
      severity of Heart failure. METHODS: We analyze 285 patients with a diagnosis of 
      Congestive heart failure admitted in Lady Reading Hospital Peshawar from March 
      1(st) to August 2016. Age group of patients was 17- 67 years. New York Health 
      Association (NYHA) scoring were used to access the severity of Congestive Heart 
      Failure. Serum UA level >7.0 mg/dl was considered high. RESULTS: Total 285 
      patients with CHF were analyzed with a mean age of 54+/-2.8 years in which males 
      were 65.96% and 34.03% were female. 40% were in class II of New York Health 
      Association (NYHA), 32.63% in class III and 25.61% in class IV and 1.75% were in 
      class I. Out of 285, 59.29% met the definition of hyperuricemia. In which 83.43% 
      were male and 16.57% were female. Most of the Hyperuricemic patients 62.13% were 
      in age group of 51- 60 years, with a mean age of 57+/-4.5 years. We found a 
      significant correlation between uric acid level and BNP (p= <0.001), and use of 
      diuretics (p=<0.001). 34.93% of the Hyperuricemic CHF patients were in NYHA III 
      and NYHA IV whose SUA was above 8 mg/dl as compared to 31.57% Hyperuricemic CHF 
      patients whose SUA was below 8 mg/dl. CONCLUSION: High serum Uric acid was 
      observed in 59.29% of patients with CHF. The observed significant correlation 
      between UA level and some established prognostic markers in these patients may 
      indicate that serum UA could provide additional prognostic information in this 
      population. SUA as a marker can be measured anywhere at a low cost to help 
      identify high-risk patients with CHF. Lowing uric acid is expected to be a new 
      approach for prevention and therapy of HF.
FAU - Khan, Adnan
AU  - Khan A
AD  - Adnan Khan, House Officer, Rehman Medical Institute, Peshawar Pakistan.
FAU - Shah, Mohammad Hassan
AU  - Shah MH
AD  - Mohammad Hassan Shah, Final Year Students (MBBS), Rehman Medical College, 
      Peshawar Pakistan.
FAU - Khan, Sarbiland
AU  - Khan S
AD  - Sarbiland Khan, Final Year Students (MBBS), Rehman Medical College, Peshawar 
      Pakistan.
FAU - Shamim, Umama
AU  - Shamim U
AD  - Umama Shamim, Final Year Students (MBBS), Rehman Medical College, Peshawar 
      Pakistan.
FAU - Arshad, Sanan
AU  - Arshad S
AD  - Sanan Arshad, Final Year Students (MBBS), Rehman Medical College, Peshawar 
      Pakistan.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Med Sci
JT  - Pakistan journal of medical sciences
JID - 100913117
PMC - PMC5432699
OTO - NOTNLM
OT  - Heart failure
OT  - Risk factor
OT  - Uric acid
EDAT- 2017/05/20 06:00
MHDA- 2017/05/20 06:01
PMCR- 2017/03/01
CRDT- 2017/05/20 06:00
PHST- 2017/05/20 06:00 [entrez]
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2017/05/20 06:01 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - PJMS-33-330 [pii]
AID - 10.12669/pjms.332.11779 [doi]
PST - ppublish
SO  - Pak J Med Sci. 2017 Mar-Apr;33(2):330-334. doi: 10.12669/pjms.332.11779.