PMID- 28523165
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 9
IP  - 4
DP  - 2017 Apr
TI  - Plasma levels of matrix metalloproteinase 9 in patients undergoing off-pump 
      coronary artery bypass grafting.
PG  - 1100-1106
LID - 10.21037/jtd.2017.03.156 [doi]
AB  - BACKGROUND: Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk 
      predictor in patients with cardiovascular diseases. However, little is known 
      about the significance of increased plasma MMP9 in patients with perioperative 
      myocardial injury. We aimed to investigate the role of MMP9 in the occurrence of 
      myocardial injury during off-pump coronary artery bypass grafting (OPCAB). 
      METHODS: A total of 34 consecutive patients with coronary artery diseases (CAD) 
      were recruited in this prospective, observational study. All patients were 
      operated for OPCAB surgery. Serial blood samples were collected preoperatively 
      and 12 hours after surgery. MMP9, together with cardiac troponin I (cTnI), 
      creatinine kinase myocardial b fraction (CK-MB), C-reactive protein (CRP), and 
      N-terminal pro B-type natriuretic peptide (NT-proBNP) levels in plasma were 
      measured at each time-point. RESULTS: MMP9 levels increased significantly at 12 
      hours after surgery, attaining nearly 2 times the baseline levels (P=0.0001). 
      There was a significant correlation between preoperative (pre-OP) circulating 
      levels of MMP9 and the left ventricular ejection fraction (LVEF) (r=0.48; 
      P=0.004) as well as European System for Cardiac Operative Risk Evaluation 
      (EuroSCORE) II (r=0.43; P=0.012). Patients were in New York Heart Association 
      (NYHA) functional class III or IV heart failure showed a significantly higher 
      MMP9 levels (1,348.0+/-337.2 vs. 630.4+/-93.0 ng/L, P=0.012) as compared to the 
      patients in NYHA functional class I and II. No significant correlation was 
      observed between MMP9 and age (P=0.612), serum creatinine (P=0.185), CRP 
      (P=0.207), NT-proBNP (P=0.058). A significant correlation was observed in these 
      data between the post-OP MMP9 and cTnI (r=0.35; P=0.003). CONCLUSIONS: Our study 
      first established a connection between MMP9 and OPCAB procedure, suggesting that 
      MMP9 could be a novel biomarker for identifying perioperative myocardial injury 
      in patients undergoing OPCAB.
FAU - Li, Haiqing
AU  - Li H
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Yuan, Zhize
AU  - Yuan Z
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Li, Sen
AU  - Li S
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Qi, Quan
AU  - Qi Q
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Zhou, Mi
AU  - Zhou M
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Cai, Junfeng
AU  - Cai J
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Chen, Anqing
AU  - Chen A
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Wang, Zhe
AU  - Wang Z
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Ye, Xiaofeng
AU  - Ye X
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
FAU - Zhao, Qiang
AU  - Zhao Q
AD  - Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University 
      School of Medicine, Shanghai 200025, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC5418257
OTO - NOTNLM
OT  - Myocardial injury
OT  - matrix metalloproteinase 9 (MMP9)
OT  - off-pump coronary artery bypass grafting (OPCAB)
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2017/05/20 06:00
MHDA- 2017/05/20 06:01
PMCR- 2017/04/01
CRDT- 2017/05/20 06:00
PHST- 2017/05/20 06:00 [entrez]
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2017/05/20 06:01 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - jtd-09-04-1100 [pii]
AID - 10.21037/jtd.2017.03.156 [doi]
PST - ppublish
SO  - J Thorac Dis. 2017 Apr;9(4):1100-1106. doi: 10.21037/jtd.2017.03.156.