PMID- 28523227
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20210109
IS  - 2162-3279 (Electronic)
VI  - 7
IP  - 5
DP  - 2017 May
TI  - Parental brain-derived neurotrophic factor genotype, child prosociality, and 
      their interaction as predictors of parents' warmth.
PG  - e00685
LID - 10.1002/brb3.685 [doi]
LID - e00685
AB  - BACKGROUND: Parental warmth has been associated with various child behaviors, 
      from effortful control to callous-unemotional traits. Factors that have been 
      shown to affect parental warmth include heritability and child behavior. However, 
      there is limited knowledge about which specific genes are involved, how they 
      interact with child behavior, how they affect differential parenting, and how 
      they affect fathers. We examined what affects paternal and maternal warmth by 
      focusing on the child's prosocial behavior and parents' genotype, specifically a 
      Valine to Methionine substitution at codon 66 in the brain-derived neurotrophic 
      factor (BDNF) gene. METHODS: Data was available from a sample of 6.5 year-old 
      twins, consisting of 369 mothers and 663 children and 255 fathers and 458 
      children. Self-reports were used to assess mothers' and fathers' warmth. Child 
      prosociality was assessed with the other-parent report and experimental 
      assessments. RESULTS: Mothers' warmth was not affected by their BDNF genotype, 
      neither as a main effect nor in an interaction with child prosociality. Fathers 
      with the Met allele scored higher on warmth. Additionally, there was a 
      significant interaction between fathers' BDNF genotype and child prosociality. 
      For fathers with the Met allele there was a positive association between warmth 
      and child prosociality. Conversely, for fathers with the Val/Val genotype there 
      was no association between warmth and child prosociality. Results were repeated 
      longitudinally in a subsample with data on age 8-9 years. A direct within family 
      analysis showed that fathers with the Met allele were more likely than Val/Val 
      carriers to exhibit differential parenting toward twins who differed in their 
      prosocial behavior. The same pattern of findings was found with mother-rated and 
      experimentally assessed prosociality. CONCLUSIONS: These results shed light on 
      the genetic and environmental underpinnings of paternal behavior and differential 
      parenting.
FAU - Avinun, Reut
AU  - Avinun R
AUID- ORCID: 0000-0002-3281-1268
AD  - Department of Psychology The Hebrew University of Jerusalem Jerusalem Israel.
FAU - Knafo-Noam, Ariel
AU  - Knafo-Noam A
AUID- ORCID: 0000-0003-0613-1960
AD  - Department of Psychology The Hebrew University of Jerusalem Jerusalem Israel.
LA  - eng
PT  - Journal Article
PT  - Twin Study
DEP - 20170404
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - *Child Behavior/physiology/psychology
MH  - Empathy/*genetics
MH  - Fathers/*psychology
MH  - Female
MH  - Gene-Environment Interaction
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Mothers/*psychology
MH  - Parent-Child Relations
MH  - Parenting/*psychology
MH  - Self Report
MH  - Social Behavior
PMC - PMC5434190
OTO - NOTNLM
OT  - fathers
OT  - gene-environment interaction
OT  - parenting
OT  - prosocial behavior
OT  - the brain-derived neurotrophic factor gene
OT  - warmth
EDAT- 2017/05/20 06:00
MHDA- 2018/11/06 06:00
PMCR- 2017/04/04
CRDT- 2017/05/20 06:00
PHST- 2017/02/13 00:00 [received]
PHST- 2017/02/16 00:00 [accepted]
PHST- 2017/05/20 06:00 [entrez]
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2017/04/04 00:00 [pmc-release]
AID - BRB3685 [pii]
AID - 10.1002/brb3.685 [doi]
PST - epublish
SO  - Brain Behav. 2017 Apr 4;7(5):e00685. doi: 10.1002/brb3.685. eCollection 2017 May.