PMID- 28523527
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20181113
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 38
IP  - 3
DP  - 2018 Jun
TI  - Impact of estimated glomerular filtration rate on diabetic macular edema.
PG  - 1043-1050
LID - 10.1007/s10792-017-0557-8 [doi]
AB  - PURPOSE: Diabetic macular edema (DME) is a major cause of visual impairment in 
      patients with diabetes and is influenced by various systemic factors. This study 
      evaluates the effect of renal status on DME using estimated glomerular filtration 
      rate (eGFR) as a study marker. METHODS: This was a prospective observational 
      cross-sectional study. One hundred and ninety-five patients of diabetic 
      retinopathy (DR) were included. Group 1 had patients of DR without DME (n = 100), 
      and group 2 had patients of DR with DME (n = 95). All patients were evaluated for 
      DR/DME-related risk factors. eGFR was calculated in all patients. Spectral domain 
      optical coherence tomography (SDOCT) was done to identify the various patterns 
      and severity of DME. RESULTS: Group 2 patients had significantly higher 
      comorbidities than those in group 1 (p < 0.001). Hba1c, total cholesterol, 
      triglycerides, LDL/HDL ratio, systolic and diastolic blood pressures were 
      significantly higher in group II (p < 0.001 in each). There was no significant 
      difference between the groups in terms of blood urea, serum creatinine or eGFR. 
      eGFR did not show a significant association with a specific SDOCT pattern or 
      severity of DME. CONCLUSION: Comorbidities are more common and more severe in 
      patients with DME. However, eGFR as a marker was not useful in predicting either 
      the severity or pattern of DME. eGFR, in its present form, may not be useful in 
      the evaluation and management of patients with DME.
FAU - Temkar, Shreyas
AU  - Temkar S
AD  - Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India 
      Institute of Medical Sciences, New Delhi, 110029, India.
FAU - Karuppaiah, Nishanthini
AU  - Karuppaiah N
AD  - Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India 
      Institute of Medical Sciences, New Delhi, 110029, India.
FAU - Takkar, Brijesh
AU  - Takkar B
AD  - Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India 
      Institute of Medical Sciences, New Delhi, 110029, India.
FAU - Bhowmik, Dipankar
AU  - Bhowmik D
AD  - Department of Nephrology, All India Institute of Medical Sciences, New Delhi, 
      110029, India.
FAU - Tripathi, Manjari
AU  - Tripathi M
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      110029, India.
FAU - Ramakrishnan, Sivasubramanian
AU  - Ramakrishnan S
AD  - Department of Cardiology, All India Institute of Medical Sciences, New Delhi, 
      110029, India.
FAU - Sharma, Yog Raj
AU  - Sharma YR
AD  - Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India 
      Institute of Medical Sciences, New Delhi, 110029, India.
FAU - Vohra, Rajpal
AU  - Vohra R
AD  - Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India 
      Institute of Medical Sciences, New Delhi, 110029, India.
FAU - Chawla, Rohan
AU  - Chawla R
AD  - Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India 
      Institute of Medical Sciences, New Delhi, 110029, India.
FAU - Venkatesh, Pradeep
AU  - Venkatesh P
AD  - Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India 
      Institute of Medical Sciences, New Delhi, 110029, India. venkyprao@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170518
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
SB  - IM
MH  - Cross-Sectional Studies
MH  - Diabetic Nephropathies/complications/*physiopathology
MH  - Diabetic Retinopathy/*complications/diagnosis/physiopathology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate/*physiology
MH  - Humans
MH  - Macular Edema/diagnosis/etiology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
OTO - NOTNLM
OT  - Diabetic macular edema
OT  - Diabetic nephropathy
OT  - Diabetic retinopathy
OT  - Estimated glomerular filtration rate
EDAT- 2017/05/20 06:00
MHDA- 2018/07/18 06:00
CRDT- 2017/05/20 06:00
PHST- 2016/11/30 00:00 [received]
PHST- 2017/05/10 00:00 [accepted]
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2017/05/20 06:00 [entrez]
AID - 10.1007/s10792-017-0557-8 [pii]
AID - 10.1007/s10792-017-0557-8 [doi]
PST - ppublish
SO  - Int Ophthalmol. 2018 Jun;38(3):1043-1050. doi: 10.1007/s10792-017-0557-8. Epub 
      2017 May 18.