PMID- 28524827
OWN - NLM
STAT- MEDLINE
DCOM- 20180226
LR  - 20181202
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 130
IP  - 11
DP  - 2017 Jun 5
TI  - Impact of Human Leukocyte Antigen Loci and Haplotypes on Intestinal Acute 
      Graft-versus-host Disease after Human Leukocyte Antigen-matched Sibling 
      Peripheral Blood Stem Cell Transplantation.
PG  - 1290-1295
LID - 10.4103/0366-6999.206356 [doi]
AB  - BACKGROUND: Acute graft-versus-host disease (aGVHD) is a common and severe 
      complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). 
      Some studies have found that the presence of certain specific human leukocyte 
      antigen (HLA) loci could affect the occurrence of aGVHD. Meanwhile, the impact of 
      HLA haplotypes on aGVHD has been rarely studied. This study aimed to investigate 
      the effects of HLA loci and haplotypes on intestinal aGVHD. METHODS: Totally, 345 
      consecutive patients undergoing first HLA-matched sibling peripheral blood stem 
      cell transplantation (PBSCT) from February 2004 to June 2013 at Institute of 
      Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and 
      Peking Union Medical College, were enrolled in this study. HLA loci and 
      haplotypes of recipients with frequency over 5% were searched and their effects 
      on intestinal aGVHD were investigated. Other important factors including donor 
      age, recipient age, donor-recipient sex combinations, and conditioning regimens 
      were also evaluated using logistic regression. Pure upper gastrointestinal tract 
      aGVHD without diarrhea was excluded because the histological proof was 
      unavailable. The follow-up end-point was 6 months after HSCT. RESULTS: The 
      cumulative incidence of intestinal aGVHD was 19.4%, with 18.0% of the patients 
      classified as classic aGVHD and 1.4% as persistent, recurrent, or late aGVHD. 
      Multivariate analysis showed that HLA-A31 locus (odds ratio [OR] 2.893, 95% 
      confidence interval [CI] [1.054, 7.935], P = 0.039), HLA B40-DR15 (OR 3.133, 95% 
      CI [1.250, 7.857], P = 0.015), and HLA B46-DR9 haplotypes (OR 2.580, 95% CI 
      [1.070, 6.220], P = 0.035), female donor for male recipient (OR 2.434, 95% CI 
      [1.319, 4.493], P = 0.004) were risk factors for intestinal aGVHD. CONCLUSION: 
      The presence of certain HLA loci and haplotypes may influence the occurrence of 
      intestinal aGVHD in PBSCT with HLA-identical sibling donors.
FAU - Yan, Fa-Hong
AU  - Yan FH
AD  - Hematopoietic Stem Cell Transplantation Center, Institute of Hematology and Blood 
      Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Tianjin 300020; Department of Hematology, Weifang People's Hospital, 
      Weifang, Shandong 261041, China.
FAU - Wang, Mei
AU  - Wang M
AD  - Hematopoietic Stem Cell Transplantation Center, Institute of Hematology and Blood 
      Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Tianjin 300020, China.
FAU - Yao, Jian-Feng
AU  - Yao JF
AD  - Hematopoietic Stem Cell Transplantation Center, Institute of Hematology and Blood 
      Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Tianjin 300020, China.
FAU - Jiang, Er-Lie
AU  - Jiang EL
AD  - Hematopoietic Stem Cell Transplantation Center, Institute of Hematology and Blood 
      Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Tianjin 300020, China.
FAU - Han, Ming-Zhe
AU  - Han MZ
AD  - Hematopoietic Stem Cell Transplantation Center, Institute of Hematology and Blood 
      Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Tianjin 300020, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft vs Host Disease/*genetics
MH  - HLA Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Intestinal Mucosa/*metabolism
MH  - Intestines/*pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Peripheral Blood Stem Cell Transplantation/methods
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
PMC - PMC5455037
COIS- There are no conflicts of interest.
EDAT- 2017/05/20 06:00
MHDA- 2018/02/27 06:00
PMCR- 2017/06/05
CRDT- 2017/05/20 06:00
PHST- 2017/05/20 06:00 [entrez]
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2018/02/27 06:00 [medline]
PHST- 2017/06/05 00:00 [pmc-release]
AID - ChinMedJ_2017_130_11_1290_206356 [pii]
AID - CMJ-130-1290 [pii]
AID - 10.4103/0366-6999.206356 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2017 Jun 5;130(11):1290-1295. doi: 10.4103/0366-6999.206356.