PMID- 28525671
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20191210
IS  - 1724-6040 (Electronic)
IS  - 0391-3988 (Linking)
VI  - 40
IP  - 5
DP  - 2017 May 29
TI  - Infection in critically ill pediatric patients on continuous renal replacement 
      therapy.
PG  - 224-229
LID - 10.5301/ijao.5000587 [doi]
AB  - INTRODUCTION: Continuous renal replacement therapies (CRRT) are frequently used 
      in critically ill children and may increase the risk of infection. However, the 
      incidence, characteristics and prognosis of infection in critically ill children 
      on CRRT have not been studied. METHODS: Data from a prospective, single-center 
      register of critically ill children treated with CRRT was analyzed. RESULTS: 55 
      children (40% under 1 year of age) were treated with CRRT between June 2008 and 
      January 2012; 43 patients (78.2%) presented 1 or more infections. The most common 
      condition of patients requiring CRRT was heart disease (69%). Infection occurred 
      a median of 11 days after the initiation of CRRT (IQ range: 4 to 21 days). A 
      total of 21 patients (48.8 %) developed 1 infection, 7 (16.2%) developed 2 
      infections and 15 (34.9%) developed 3 or more infections. The most frequent 
      infection was catheter-related bacteremia, with no differences in catheter 
      location. CRRT duration longer than 4.5 days was the only risk factor for 
      infection. Patients with infection had a longer length of stay (LOS) in the 
      Pediatric Intensive Care Unit (PICU) than patients without it (37.8 vs. 17.6, p = 
      0.019), but there were no differences in mortality (30.2% vs. 33.3%; p = 0.84). 
      CONCLUSIONS: Infection rate is high in critically ill children treated with CRRT. 
      More than 4 days of CRRT increases the risk of infection. Infection in these 
      patients entails a longer stay in the PICU but did not increase mortality.
FAU - Santiago, Maria J
AU  - Santiago MJ
AD  - Pediatric Intensive Care Department, Health Research Institute, Gregorio Maranon 
      General University Hospital of Madrid, School of Medicine, Complutense University 
      of Madrid, Madrid - Spain.
FAU - Lopez-Herce, Jesus
AU  - Lopez-Herce J
AD  - Pediatric Intensive Care Department, Health Research Institute, Gregorio Maranon 
      General University Hospital of Madrid, School of Medicine, Complutense University 
      of Madrid, Madrid - Spain.
FAU - Vierge, Eva
AU  - Vierge E
AD  - Pediatric Intensive Care Department, Health Research Institute, Gregorio Maranon 
      General University Hospital of Madrid, School of Medicine, Complutense University 
      of Madrid, Madrid - Spain.
FAU - Castillo, Ana
AU  - Castillo A
AD  - Pediatric Intensive Care Department, Health Research Institute, Gregorio Maranon 
      General University Hospital of Madrid, School of Medicine, Complutense University 
      of Madrid, Madrid - Spain.
FAU - Bustinza, Amaya
AU  - Bustinza A
AD  - Pediatric Intensive Care Department, Health Research Institute, Gregorio Maranon 
      General University Hospital of Madrid, School of Medicine, Complutense University 
      of Madrid, Madrid - Spain.
FAU - Bellon, Jose M
AU  - Bellon JM
AD  - Department of Statistics, Health Research Institute, Gregorio Maranon General 
      University Hospital of Madrid, School of Medicine, Complutense University of 
      Madrid, Madrid - Spain.
FAU - Sanchez, Amelia
AU  - Sanchez A
AD  - Pediatric Intensive Care Department, Health Research Institute, Gregorio Maranon 
      General University Hospital of Madrid, School of Medicine, Complutense University 
      of Madrid, Madrid - Spain.
FAU - Fernandez, Sarah
AU  - Fernandez S
AD  - Pediatric Intensive Care Department, Health Research Institute, Gregorio Maranon 
      General University Hospital of Madrid, School of Medicine, Complutense University 
      of Madrid, Madrid - Spain.
LA  - eng
PT  - Journal Article
DEP - 20170518
PL  - United States
TA  - Int J Artif Organs
JT  - The International journal of artificial organs
JID - 7802649
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *Critical Illness
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Infections/*epidemiology/*etiology
MH  - Length of Stay
MH  - Male
MH  - Prognosis
MH  - Prospective Studies
MH  - Registries
MH  - Renal Replacement Therapy/*adverse effects
MH  - Risk Factors
EDAT- 2017/05/20 06:00
MHDA- 2018/02/13 06:00
CRDT- 2017/05/20 06:00
PHST- 2017/03/17 00:00 [accepted]
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
PHST- 2017/05/20 06:00 [entrez]
AID - 9F686B27-826D-470C-A1A3-721978356C60 [pii]
AID - 10.5301/ijao.5000587 [doi]
PST - ppublish
SO  - Int J Artif Organs. 2017 May 29;40(5):224-229. doi: 10.5301/ijao.5000587. Epub 
      2017 May 18.