PMID- 28526222
OWN - NLM
STAT- MEDLINE
DCOM- 20170907
LR  - 20181215
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 187
DP  - 2017 Aug
TI  - Hemocytometric Measures Predict the Efficacy of Oral Rehydration for Children 
      with Postural Tachycardia Syndrome.
PG  - 220-224
LID - S0022-3476(17)30580-2 [pii]
LID - 10.1016/j.jpeds.2017.04.034 [doi]
AB  - OBJECTIVE: To explore whether hemocytometric measures could be qualified 
      predictors for the effect of oral rehydration salts (ORS) in children with 
      postural tachycardia syndrome (POTS). STUDY DESIGN: Thirty-five children with 
      POTS and 29 healthy children were enrolled. General information, hemodynamic 
      status, and baseline hemocytometric variables were collected. Children with POTS 
      received ORS therapy and were followed up for 3 months. The independent risk 
      factors of developing POTS were explored. A receiver-operating characteristic 
      curve was used to evaluate predictive value of hemocytometric variables for 
      therapeutic effectiveness of ORS therapy. RESULTS: Children with POTS had larger 
      mean corpuscular volume (MCV) and lower mean corpuscular hemoglobin concentration 
      (MCHC) values than controls (P < .05). The baseline MCV values positively 
      correlated with heart rate elevation from supine to upright (r = 0.294, P < .05). 
      Both larger MCV and lower MCHC values were independent risk factors of developing 
      POTS (for MCV, P < .05, OR 1.222; for MCHC, P < .05, OR 0.936). In children with 
      POTS, responders to ORS had baseline lower MCV and higher MCHC than nonresponders 
      (P < .05). The receiver-operating characteristic curve for the predictive value 
      of MCHC showed that area under the curve was 0.73. CONCLUSIONS: MCHC values could 
      be used to predict the effectiveness of ORS for treating POTS in children.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Lu, Wenxin
AU  - Lu W
AD  - Department of Pediatrics, Peking University First Hospital, Beijing, China.
FAU - Yan, Hui
AU  - Yan H
AD  - Department of Pediatrics, Peking University First Hospital, Beijing, China.
FAU - Wu, Shu
AU  - Wu S
AD  - Department of Pediatrics, Peking University First Hospital, Beijing, China.
FAU - Xu, Wenrui
AU  - Xu W
AD  - Department of Pediatrics, Peking University First Hospital, Beijing, China.
FAU - Jin, Hongfang
AU  - Jin H
AD  - Department of Pediatrics, Peking University First Hospital, Beijing, China.
FAU - Du, Junbao
AU  - Du J
AD  - Department of Pediatrics, Peking University First Hospital, Beijing, China. 
      Electronic address: junbaodu1@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170516
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fluid Therapy/*methods
MH  - Follow-Up Studies
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Male
MH  - Postural Orthostatic Tachycardia Syndrome/*physiopathology/therapy
MH  - ROC Curve
MH  - Treatment Outcome
OTO - NOTNLM
OT  - erythrocyte
OT  - oral rehydration salts
OT  - postural tachycardia syndrome
OT  - treatment
EDAT- 2017/05/21 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/05/21 06:00
PHST- 2017/01/13 00:00 [received]
PHST- 2017/04/04 00:00 [revised]
PHST- 2017/04/17 00:00 [accepted]
PHST- 2017/05/21 06:00 [pubmed]
PHST- 2017/09/08 06:00 [medline]
PHST- 2017/05/21 06:00 [entrez]
AID - S0022-3476(17)30580-2 [pii]
AID - 10.1016/j.jpeds.2017.04.034 [doi]
PST - ppublish
SO  - J Pediatr. 2017 Aug;187:220-224. doi: 10.1016/j.jpeds.2017.04.034. Epub 2017 May 
      16.