PMID- 28526531
OWN - NLM
STAT- MEDLINE
DCOM- 20180315
LR  - 20180315
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 471
DP  - 2017 Aug
TI  - Detection of high serum concentration of CXC chemokine ligand-12 in acute 
      intracerebral hemorrhage.
PG  - 55-61
LID - S0009-8981(17)30186-9 [pii]
LID - 10.1016/j.cca.2017.05.022 [doi]
AB  - BACKGROUND: CXC chemokine ligand-12 (CXCL12), a member of the CXC chemokine 
      subfamily, is involved in both focal angiogenesis and inflammatory reactions. We 
      examined serum CXCL12 concentration in intracerebral hemorrhage (ICH) patients 
      and its correlation to stroke severity and outcome. METHODS: The study was 
      carried out on 105 ICH patients on 105 healthy controls. Serum samples were at 
      admission obtained to measure CXCL12 concentrations. The National Institutes of 
      Health Stroke Scale (NIHSS) and hematoma volume were recorded to assess stroke 
      severity. RESULTS: As compared to the controls, CXCL12 concentrations were 
      significantly increased in the patients. Also, non-survivors within 6months and 
      patients with an unfavorable outcome (modified Rankin Scale score>2) at 6months 
      had higher CXCL12 concentrations than other remaining ones. CXCL12 concentrations 
      had positive correlation with NIHSS scores and hematoma volume. Serum CXCL12 
      significantly discriminated patients at risk of 6-month mortality and 6-month 
      unfavorable outcome under receiver operating characteristic curve. Moreover, 
      serum CXCL12 was independently associated with the mortality, overall survival 
      and unfavorable outcome. CONCLUSIONS: Serum CXCL12 concentrations are enhanced 
      after ICH and CXCL12 in serum has the potential to reflect severity and prognosis 
      following hemorrhagic stroke.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Shen, Jia
AU  - Shen J
AD  - Department of Neurosurgery, The First People's Hospital of Fuyang District of 
      Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
FAU - Chen, Bin
AU  - Chen B
AD  - Department of Neurosurgery, The First People's Hospital of Fuyang District of 
      Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
FAU - Zheng, Guan-Rong
AU  - Zheng GR
AD  - Department of Neurosurgery, The First People's Hospital of Fuyang District of 
      Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
FAU - Qiu, Shen-Zhong
AU  - Qiu SZ
AD  - Department of Neurosurgery, The First People's Hospital of Fuyang District of 
      Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China. 
      Electronic address: weiaanggg@163.com.
FAU - Yin, Huai-Ming
AU  - Yin HM
AD  - Department of Neurosurgery, The First People's Hospital of Fuyang District of 
      Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
FAU - Mao, Wei
AU  - Mao W
AD  - Department of Neurosurgery, The First People's Hospital of Fuyang District of 
      Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
FAU - Wang, Hong-Xiang
AU  - Wang HX
AD  - Department of Neurology, The First People's Hospital of Fuyang District of 
      Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
FAU - Gao, Jian-Bo
AU  - Gao JB
AD  - Department of Emergency Medicine, The First People's Hospital of Fuyang District 
      of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
LA  - eng
PT  - Journal Article
DEP - 20170516
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Chemokine CXCL12)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Case-Control Studies
MH  - Cerebral Hemorrhage/*blood/complications/diagnosis/mortality
MH  - Chemokine CXCL12/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Stroke/complications
OTO - NOTNLM
OT  - CXC chemokine ligand-12
OT  - Functional outcome
OT  - Intracerebral hemorrhage
OT  - Mortality
OT  - Prognosis
OT  - Severity
EDAT- 2017/05/21 06:00
MHDA- 2018/03/16 06:00
CRDT- 2017/05/21 06:00
PHST- 2017/04/30 00:00 [received]
PHST- 2017/05/11 00:00 [revised]
PHST- 2017/05/15 00:00 [accepted]
PHST- 2017/05/21 06:00 [pubmed]
PHST- 2018/03/16 06:00 [medline]
PHST- 2017/05/21 06:00 [entrez]
AID - S0009-8981(17)30186-9 [pii]
AID - 10.1016/j.cca.2017.05.022 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2017 Aug;471:55-61. doi: 10.1016/j.cca.2017.05.022. Epub 2017 May 
      16.