PMID- 2852685
OWN - NLM
STAT- MEDLINE
DCOM- 19890418
LR  - 20190919
IS  - 0260-437X (Print)
IS  - 0260-437X (Linking)
VI  - 8
IP  - 6
DP  - 1988 Dec
TI  - Assessment of the relative hazard involved with airborne irritants with 
      additional hepatotoxic or nephrotoxic properties in mice.
PG  - 417-22
AB  - This paper deals with the conversion of the hepatotoxicity of 1,2-dichlorobenzene 
      (DCB), the nephrotoxicity of hexachloro-1,3-butadiene (HCBD) and the respiratory 
      effects of these two toxicants into quantal data. It aims to provide some useful 
      information on the best strategy used for safety evaluation. A reflex bradypnea 
      indicative of irritation of the nasal cavities of mice occurred during a 15-min 
      oronasal exposure to each chemical. A reduction in the development of staining 
      for liver glucose-6-phosphatase (G6-phosphatase) and an increase in the number of 
      damaged tubules in cryostat kidney sections stained for alkaline phosphatase were 
      the measure of toxicity in mice subjected to a whole-body 4-h exposure to DCB and 
      HCBD vapours, respectively. The immediate irritant responses, as well as the 
      delayed liver and kidney responses, were measured at the peak of the chemical's 
      action. These maximum responses were then used to establish the relationships of 
      exposure level effects and also the median active levels of exposure (MALs). The 
      DCB and HCBD MALs responsible for a 50% decrease in the respiratory rate of mice 
      (RD50) were 181 and 211 ppm, respectively. The MAL required for eliciting a 50% 
      decrease in G6-phosphatase staining intensity in DCB-exposed mice was 598 ppm and 
      that associated with 50% of damaged tubules in HCBD-exposed mice was 7.2 ppm. On 
      the basis of these quantitative data, potency ratios indicated that irritation 
      and kidney injury are the primary manifestations of toxicity associated with 
      short-term exposure to DCB and HCBD, respectively.(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - De Ceaurriz, J
AU  - De Ceaurriz J
AD  - Institut National de Recherche et de Securite, Vandoeuvre, France.
FAU - Gagnaire, F
AU  - Gagnaire F
FAU - Ban, M
AU  - Ban M
FAU - Bonnet, P
AU  - Bonnet P
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Appl Toxicol
JT  - Journal of applied toxicology : JAT
JID - 8109495
RN  - 0 (Air Pollutants)
RN  - 0 (Butadienes)
RN  - 0 (Chlorobenzenes)
RN  - 0 (Irritants)
RN  - 6PJ93I88XL (2-dichlorobenzene)
RN  - CQ8AAO9MO1 (hexachlorobutadiene)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - EC 3.1.3.9 (Glucose-6-Phosphatase)
SB  - IM
MH  - Air Pollutants/*toxicity
MH  - Alkaline Phosphatase/analysis
MH  - Animals
MH  - Butadienes/toxicity
MH  - Chemical and Drug Induced Liver Injury/enzymology/*etiology
MH  - Chlorobenzenes/toxicity
MH  - Glucose-6-Phosphatase/analysis
MH  - Histocytochemistry
MH  - Irritants/*toxicity
MH  - Kidney Diseases/*chemically induced/enzymology
MH  - Male
MH  - Mice
MH  - Respiratory System/drug effects
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
AID - 10.1002/jat.2550080606 [doi]
PST - ppublish
SO  - J Appl Toxicol. 1988 Dec;8(6):417-22. doi: 10.1002/jat.2550080606.