PMID- 28527399
OWN - NLM
STAT- MEDLINE
DCOM- 20180413
LR  - 20181202
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 114
DP  - 2017 Oct
TI  - The effects of melamine with or without cyanuric acid on immune function in 
      ovalbumin-sensitized mice.
PG  - 254-261
LID - S0034-5288(16)30205-3 [pii]
LID - 10.1016/j.rvsc.2017.05.015 [doi]
AB  - Melamine is commonly used in the chemical industry, and it has been found to 
      exist on food processing equipment and utensils. Previous investigations 
      suggested that melamine alone or its combination with cyanuric acid appears to be 
      toxic to immune system in animals. The objective of this study is to investigate 
      the potential effects of melamine with or without cyanuric acid on immune 
      function in ovalbumin- sensitized mice. Our data indicated that melamine-related 
      administration caused a significant decreasing in the content of IL-4 in mice in 
      comparison to negative control group. Significant increasing in the content of 
      histamine (HIS) was recorded in almost all treated groups. The co-administration 
      of melamine and cyanuric acid with high dose (each at 16mgkg(-1)2d(-1)) led to a 
      significantly lower contents of IL-10, IL-16 and monocyte chemoattractant 
      protein-1 (MCP-1) in mouse serum in comparison to negative control group. 
      Moreover, our data indicated that the number of Th1 and Th2 cells, and the ratio 
      of Th1/Th2 spleen lymphocytes were significantly changed after treatment. Also, 
      our results demonstrated that the profiles of both CD40 and CD40L were 
      significantly altered in spleen lymphocytes after treatment.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Yin, Rong H
AU  - Yin RH
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Dong, Qiao
AU  - Dong Q
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Li, Hua S
AU  - Li HS
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Yuan, Jing
AU  - Yuan J
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Li, Xi T
AU  - Li XT
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Yin, Rong L
AU  - Yin RL
AD  - Research Academy of Animal Husbandry and Veterinary Medicine Sciences of Jilin 
      Province, Changchun 130062, PR China.
FAU - Li, Wen
AU  - Li W
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Wang, Wen C
AU  - Wang WC
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Liu, Bao S
AU  - Liu BS
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Han, Xiao H
AU  - Han XH
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Wang, Ren F
AU  - Wang RF
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Wang, Xin
AU  - Wang X
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China.
FAU - Bai, Wen L
AU  - Bai WL
AD  - Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & 
      Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China. 
      Electronic address: baiwenlin55@163.com.
LA  - eng
PT  - Journal Article
DEP - 20170513
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Environmental Pollutants)
RN  - 0 (Triazines)
RN  - 9006-59-1 (Ovalbumin)
RN  - H497R4QKTZ (cyanuric acid)
RN  - N3GP2YSD88 (melamine)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants/*toxicity
MH  - *Immunity, Innate
MH  - Male
MH  - Mice
MH  - Ovalbumin/immunology
MH  - Toxicity Tests
MH  - Triazines/*toxicity
OTO - NOTNLM
OT  - Cyanuric acid
OT  - Immune function
OT  - Melamine
OT  - Mouse
OT  - Ovalbumin
EDAT- 2017/05/21 06:00
MHDA- 2018/04/14 06:00
CRDT- 2017/05/21 06:00
PHST- 2016/08/19 00:00 [received]
PHST- 2017/05/11 00:00 [revised]
PHST- 2017/05/12 00:00 [accepted]
PHST- 2017/05/21 06:00 [pubmed]
PHST- 2018/04/14 06:00 [medline]
PHST- 2017/05/21 06:00 [entrez]
AID - S0034-5288(16)30205-3 [pii]
AID - 10.1016/j.rvsc.2017.05.015 [doi]
PST - ppublish
SO  - Res Vet Sci. 2017 Oct;114:254-261. doi: 10.1016/j.rvsc.2017.05.015. Epub 2017 May 
      13.