PMID- 28527683
OWN - NLM
STAT- MEDLINE
DCOM- 20180501
LR  - 20221207
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 179
DP  - 2017 Oct 1
TI  - Association of Val66Met polymorphism at brain derived neurotrophic factor gene 
      with depression among Chinese adolescents after Wenchuan earthquake: An 18months 
      longitudinal study.
PG  - 16-22
LID - S0031-9384(16)30992-1 [pii]
LID - 10.1016/j.physbeh.2017.05.018 [doi]
AB  - To longitudinally investigate the association of Val66Met polymorphism at brain 
      derived neurotrophic factor (BDNF) gene (BDNF) with depression in Chinese Han 
      adolescents after the 2008 Wenchuan earthquake, BDNF Val66Met was identified by 
      polymerase chain reaction-restriction fragment length polymorphism analyses and 
      verified by DNA sequencing. Depression was assessed by Beck Depression Inventory 
      (BDI) among high school students at 6, 12 and 18months after the earthquake. The 
      results showed that the females constantly had higher depression prevalence than 
      the males during the follow-up in the Met allele carriers, but not in the Val/Val 
      homozygotes. When compared to that at 6months, the prevalence was lowered at 
      12months in the male Met allele carriers, and at 18months in all the females and 
      the male Met allele carriers. Moreover, the Met allele carriers had higher BDI 
      scores than the Val/Val homozygotes only in the females at 18months. The females 
      had higher BDI scores than the males constantly during the follow-up in the Met 
      allele carriers and at 12months only in the Val/Val homozygotes. When compared to 
      those at 12months, the scores decreased at 18months in all the females and the 
      male Met allele carriers. In addition, the potential factors of prevalence or 
      predictors of severity of depression were different between the Val/Val 
      homozygotes and the Met allele carriers at different times after the earthquake. 
      The results suggest that interactions may occur after stresses among BDNF 
      Val66Met, gender and time course to influence depression. This may be one of the 
      explanations for the inconsistent relationships reported before between 
      depression and BDNF Val66Met and need to take into account for precision medical 
      and more effective interference of depression in adolescents after disasters.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Fan, Mei
AU  - Fan M
AD  - Department of Biochemistry and Molecular Biology, West China School of 
      Preclinical and Forensic Medicine, and State Key Laboratory of Oral Diseases, 
      Sichuan University, Chengdu, China.
FAU - Li, Rong Hui
AU  - Li RH
AD  - Department of Biochemistry and Molecular Biology, West China School of 
      Preclinical and Forensic Medicine, and State Key Laboratory of Oral Diseases, 
      Sichuan University, Chengdu, China.
FAU - Hu, Min Shan
AU  - Hu MS
AD  - Department of Biochemistry and Molecular Biology, West China School of 
      Preclinical and Forensic Medicine, and State Key Laboratory of Oral Diseases, 
      Sichuan University, Chengdu, China.
FAU - Xiao, Li Ying
AU  - Xiao LY
AD  - Department of Biochemistry and Molecular Biology, West China School of 
      Preclinical and Forensic Medicine, and State Key Laboratory of Oral Diseases, 
      Sichuan University, Chengdu, China.
FAU - Zhou, Xue Dong
AU  - Zhou XD
AD  - Department of Biochemistry and Molecular Biology, West China School of 
      Preclinical and Forensic Medicine, and State Key Laboratory of Oral Diseases, 
      Sichuan University, Chengdu, China.
FAU - Ran, Mao Sheng
AU  - Ran MS
AD  - Department of Social Work and Social Administration, University of Hong Kong, 
      China. Electronic address: msran@hku.hk.
FAU - Fang, Ding Zhi
AU  - Fang DZ
AD  - Department of Biochemistry and Molecular Biology, West China School of 
      Preclinical and Forensic Medicine, and State Key Laboratory of Oral Diseases, 
      Sichuan University, Chengdu, China. Electronic address: dzfang@scu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170517
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depression/epidemiology/etiology/*genetics
MH  - Disasters
MH  - Disease Progression
MH  - Earthquakes
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Prevalence
MH  - Sex Factors
MH  - Time Factors
OTO - NOTNLM
OT  - BDNF Val66Met
OT  - Genetic variation
OT  - Prevalence of depression
OT  - The Beck Depression Inventory
EDAT- 2017/05/22 06:00
MHDA- 2018/05/02 06:00
CRDT- 2017/05/22 06:00
PHST- 2016/11/02 00:00 [received]
PHST- 2017/04/11 00:00 [revised]
PHST- 2017/05/16 00:00 [accepted]
PHST- 2017/05/22 06:00 [pubmed]
PHST- 2018/05/02 06:00 [medline]
PHST- 2017/05/22 06:00 [entrez]
AID - S0031-9384(16)30992-1 [pii]
AID - 10.1016/j.physbeh.2017.05.018 [doi]
PST - ppublish
SO  - Physiol Behav. 2017 Oct 1;179:16-22. doi: 10.1016/j.physbeh.2017.05.018. Epub 
      2017 May 17.