PMID- 28527829
OWN - NLM
STAT- MEDLINE
DCOM- 20181015
LR  - 20181015
IS  - 1095-7103 (Electronic)
IS  - 0021-9797 (Linking)
VI  - 504
DP  - 2017 Oct 15
TI  - Graphene oxide nanosheets and d-alpha-Tocopheryl polyethylene glycol 1000 succinate 
      (TPGS) doping improves biocompatibility and ultrafiltration in polyethersulfone 
      hollow fiber membranes.
PG  - 86-100
LID - S0021-9797(17)30550-7 [pii]
LID - 10.1016/j.jcis.2017.05.035 [doi]
AB  - Novel graphene oxide (G)-and d-alpha-Tocopheryl polyethylene glycol 1000 succinate 
      (T)-doped polyethersulfone (P) hollow fiber membranes (GTP HFMs) were efficiently 
      prepared. GTP HFMs were found to be a desirable biocompatible substrate for 
      attachment and proliferation of human embryonic kidney-293 (HEK-293) cells. 
      Significantly high porosity (94.58+/-1.1%), low contact angle (61.1+/-2.5 degrees ), low 
      hemolysis (0.58% in batch mode and 0.64% in continuous mode), low terminal 
      complement complex activation (SC5b-9 marker level  approximately 6.73ng/mL), prolonged blood 
      coagulation time, and low platelet adhesion were measured for GTP HFMs indicating 
      the superior suitability of GTP HFMs for blood-contact applications. Further, SEM 
      and confocal laser microscopy studies showed the significantly high HEK-293 cells 
      attachment and proliferation on GTP HFMs which was corroborated by results of 
      glucose consumption analysis and MTT cell proliferation assay. High 
      ultrafiltration coefficient (110+/-3mL/m(2)/h/mmHg), and albumin solute rejection 
      (94.87+/-0.5%) were also measured for GTP HFMs. Thus, these results clearly 
      indicated that the synergistic effect of additives improved the biocompatibility 
      and ultrafiltration in GTP HFMs. The developed GTP HFMs can potentially be used 
      for simultaneous/sequential cells attachment and proliferation, and 
      ultrafiltration applications such as the bioartificial kidney.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Modi, Akshay
AU  - Modi A
AD  - Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 
      400076, India.
FAU - Verma, Surendra Kumar
AU  - Verma SK
AD  - Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 
      400076, India.
FAU - Bellare, Jayesh
AU  - Bellare J
AD  - Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 
      400076, India; Centre for Research in Nanotechnology & Sciences, Indian Institute 
      of Technology Bombay, Mumbai 400076, India; Wadhwani Research Center for 
      Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India. 
      Electronic address: jb@iitb.ac.in.
LA  - eng
PT  - Journal Article
DEP - 20170512
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 0 (Biocompatible Materials)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Oxides)
RN  - 0 (Polymers)
RN  - 0 (Sulfones)
RN  - 1406-18-4 (Vitamin E)
RN  - 25667-42-9 (polyether sulfone)
RN  - 7782-42-5 (Graphite)
RN  - O03S90U1F2 (tocophersolan)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - Blood Coagulation
MH  - Graphite/*chemistry
MH  - HEK293 Cells
MH  - Hemolysis
MH  - Humans
MH  - Materials Testing
MH  - *Membranes, Artificial
MH  - Nanostructures/*chemistry/ultrastructure
MH  - Oxides/chemistry
MH  - Platelet Adhesiveness
MH  - Polymers/*chemistry
MH  - Porosity
MH  - Sulfones/*chemistry
MH  - Ultrafiltration
MH  - Vitamin E/*chemistry
OTO - NOTNLM
OT  - Biocompatibility
OT  - Blood-contact
OT  - Doping
OT  - Graphene oxide nanosheets
OT  - HEK-293 cells attachment and proliferation
OT  - Hollow fiber membrane
OT  - Polyethersulfone
OT  - Polymer-additives compatibility
OT  - Ultrafiltration
OT  - d-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS)
EDAT- 2017/05/22 06:00
MHDA- 2018/10/16 06:00
CRDT- 2017/05/22 06:00
PHST- 2017/03/14 00:00 [received]
PHST- 2017/05/10 00:00 [revised]
PHST- 2017/05/11 00:00 [accepted]
PHST- 2017/05/22 06:00 [pubmed]
PHST- 2018/10/16 06:00 [medline]
PHST- 2017/05/22 06:00 [entrez]
AID - S0021-9797(17)30550-7 [pii]
AID - 10.1016/j.jcis.2017.05.035 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2017 Oct 15;504:86-100. doi: 10.1016/j.jcis.2017.05.035. 
      Epub 2017 May 12.