PMID- 28527954
OWN - NLM
STAT- MEDLINE
DCOM- 20180412
LR  - 20180919
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 356
DP  - 2017 Jul 25
TI  - Sex differences in the effect of chronic mild stress on mouse prefrontal cortical 
      BDNF levels: A role of major ovarian hormones.
PG  - 89-101
LID - S0306-4522(17)30345-7 [pii]
LID - 10.1016/j.neuroscience.2017.05.020 [doi]
AB  - Depression induced by stress is affected by sex, age and hormonal status of the 
      animal and also by duration and type of the stressors. Moreover, higher 
      prevalence of depression and comorbidities in women than men implies the need to 
      include the sex variable in studies on animal models of depression. The present 
      study was therefore initiated to evaluate the effect of sex and ovarian hormones 
      on depression-like phenotypes in mice exposed to a 21-day Chronic Variable Mild 
      Stress (CVMS) paradigm. Adult male, intact female and, ovariectomized (OVX) 
      female mice exposed to CVMS displayed despair behavior, a depression-like 
      phenotype, in all the groups. However, intact females alone, but not males and 
      OVX females, showed anhedonia, another depression-like phenotype. At the 
      molecular level, the expression of Brain-Derived Neurotrophic Factor (BDNF), a 
      neuropeptide associated with depression, and few other stress-specific genes CRH, 
      NR3C1, CART, and NPY were measured in the Prefrontal Cortex (PFC) region of the 
      reward circuitry. There was a significant decrease in the BDNF protein expression 
      along with an increase in the mRNA expression of CRH, NR3C1, CART, and NPY in 
      intact females, but not in the other two groups of mice. OVX females resembled 
      males in behavioral and molecular responses to CVMS. 17beta-Estradiol (E2) 
      administration, not Progesterone (P4), to OVX female stress mice, mitigated 
      despair and enhanced hedonic capacity with an increased expression of BDNF in 
      PFC. This study strengthens the evidence for the beneficial effects of E2 
      administration in stress condition.
CI  - Copyright (c) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Karisetty, Bhanu Chandra
AU  - Karisetty BC
AD  - Chemical Biology, CSIR- Indian Institute of Chemical Technology, Tarnaka, Uppal 
      Road, Hyderabad, Telangana 500007, India; Academy of Scientific and Innovative 
      Research, New Delhi, India.
FAU - Joshi, Pranav Chintamani
AU  - Joshi PC
AD  - Chemical Biology, CSIR- Indian Institute of Chemical Technology, Tarnaka, Uppal 
      Road, Hyderabad, Telangana 500007, India.
FAU - Kumar, Arvind
AU  - Kumar A
AD  - CSIR- Centre for Cellular and Molecular Biology, Habsiguda, Uppal Road, 
      Hyderabad, Telangana 500007, India; Academy of Scientific and Innovative 
      Research, New Delhi, India.
FAU - Chakravarty, Sumana
AU  - Chakravarty S
AD  - Chemical Biology, CSIR- Indian Institute of Chemical Technology, Tarnaka, Uppal 
      Road, Hyderabad, Telangana 500007, India; Academy of Scientific and Innovative 
      Research, New Delhi, India. Electronic address: sumana98@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170518
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/metabolism
MH  - Estradiol/*metabolism/pharmacology
MH  - Hippocampus/drug effects/metabolism
MH  - Mice, Inbred C57BL
MH  - Ovariectomy/methods
MH  - Prefrontal Cortex/*metabolism
MH  - Progesterone/metabolism/pharmacology
MH  - *Sex Characteristics
MH  - *Stress, Physiological/physiology
OTO - NOTNLM
OT  - CVMS model
OT  - anhedonia
OT  - depression
OT  - estrogen
OT  - ovariectomy
OT  - progesterone
EDAT- 2017/05/22 06:00
MHDA- 2018/04/13 06:00
CRDT- 2017/05/22 06:00
PHST- 2017/01/03 00:00 [received]
PHST- 2017/04/12 00:00 [revised]
PHST- 2017/05/03 00:00 [accepted]
PHST- 2017/05/22 06:00 [pubmed]
PHST- 2018/04/13 06:00 [medline]
PHST- 2017/05/22 06:00 [entrez]
AID - S0306-4522(17)30345-7 [pii]
AID - 10.1016/j.neuroscience.2017.05.020 [doi]
PST - ppublish
SO  - Neuroscience. 2017 Jul 25;356:89-101. doi: 10.1016/j.neuroscience.2017.05.020. 
      Epub 2017 May 18.