PMID- 28528429
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 33
IP  - 11
DP  - 2017 Nov
TI  - Myocardial edema in acute myocarditis: relationship of T2 relaxometry and late 
      enhancement burden by using dual-contrast turbo spin-echo MRI.
PG  - 1789-1794
LID - 10.1007/s10554-017-1170-7 [doi]
AB  - To quantify myocardial edema by using a T2 relaxometry approach with a 
      dual-contrast turbo spin-echo (dcTSE) sequence in patients with acute myocarditis 
      regarding focal late gadolinium enhancement (LGE) burden. CMR T2 relaxometry was 
      performed in 39 patients (age 41 +/- 19 years; 36% women) with LGE in a typical 
      myocarditis pattern and in ten healthy volunteers (age 46 +/- 12; 60% woman). dcTSE 
      sequence (echo time 29 and 75 ms, respectively) was used for T2 mapping, analysis 
      were performed on the basis of region of interest (ROI). Myocardial T2 relaxation 
      times (T2 RT) in patients-ROI with focal LGE were significantly (p < 0.001) 
      higher than T2 RT in patients-ROI without apparent LGE pattern (65 ms (IQR 36-95) 
      vs. 60 ms (IQR 26-88), respectively). T2 RT in healthy volunteers [55 ms (IQR 
      35-71)] were significantly lower than in patients ROI with or without focal 
      LGE-pattern (p < 0.001, respectively). T2 RT assessed by dcTSE are significantly 
      higher in patients segments with and without focal LGE compared to normal 
      controls, supporting a global myocardial inflammatory process in acute 
      myocarditis. Furthermore, this quantitative T2-mapping approach highlights the 
      potential to identify patients with diffuse myocarditis.
FAU - Mayr, A
AU  - Mayr A
AD  - University Hospital for Radiology, Medical University of Innsbruck, Anichstrasse 
      35, 6020, Innsbruck, Austria. a.mayr@i-med.ac.at.
FAU - Klug, G
AU  - Klug G
AD  - University Hospital for Internal Medicine III (Cardiology and Angiology), Medical 
      University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
FAU - Feistritzer, H J
AU  - Feistritzer HJ
AD  - University Hospital for Internal Medicine III (Cardiology and Angiology), Medical 
      University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
FAU - Reinstadler, S J
AU  - Reinstadler SJ
AD  - University Hospital for Internal Medicine III (Cardiology and Angiology), Medical 
      University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
FAU - Reindl, M
AU  - Reindl M
AD  - University Hospital for Internal Medicine III (Cardiology and Angiology), Medical 
      University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
FAU - Esterhammer, R
AU  - Esterhammer R
AD  - University Hospital for Radiology, Medical University of Innsbruck, Anichstrasse 
      35, 6020, Innsbruck, Austria.
FAU - Feuchtner, G
AU  - Feuchtner G
AD  - University Hospital for Radiology, Medical University of Innsbruck, Anichstrasse 
      35, 6020, Innsbruck, Austria.
FAU - Metzler, B
AU  - Metzler B
AD  - University Hospital for Internal Medicine III (Cardiology and Angiology), Medical 
      University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
FAU - Schocke, M F
AU  - Schocke MF
AD  - University Hospital for Radiology, Medical University of Innsbruck, Anichstrasse 
      35, 6020, Innsbruck, Austria.
LA  - eng
PT  - Journal Article
DEP - 20170520
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Contrast Media/*administration & dosage
MH  - Edema, Cardiac/*diagnostic imaging/pathology/physiopathology
MH  - Female
MH  - Humans
MH  - *Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Meglumine/administration & dosage/*analogs & derivatives
MH  - Middle Aged
MH  - Myocarditis/*diagnostic imaging/pathology/physiopathology
MH  - Myocardium/pathology
MH  - Organometallic Compounds/*administration & dosage
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Ventricular Function, Left
MH  - Young Adult
PMC - PMC5682853
OTO - NOTNLM
OT  - Acute myocarditis
OT  - Cardiac magnetic resonance
OT  - Left ventricular function
OT  - T2 relaxometry
OT  - TroponinT
COIS- The authors declare that they have no conflict of interest to declare.
EDAT- 2017/05/22 06:00
MHDA- 2018/01/06 06:00
PMCR- 2017/05/20
CRDT- 2017/05/22 06:00
PHST- 2017/02/14 00:00 [received]
PHST- 2017/05/17 00:00 [accepted]
PHST- 2017/05/22 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2017/05/22 06:00 [entrez]
PHST- 2017/05/20 00:00 [pmc-release]
AID - 10.1007/s10554-017-1170-7 [pii]
AID - 1170 [pii]
AID - 10.1007/s10554-017-1170-7 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2017 Nov;33(11):1789-1794. doi: 
      10.1007/s10554-017-1170-7. Epub 2017 May 20.