PMID- 28528961
OWN - NLM
STAT- MEDLINE
DCOM- 20180403
LR  - 20180403
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 209
DP  - 2017 Sep
TI  - GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) as a target 
      for homologous and broadly neutralizing antibodies.
PG  - 90-96
LID - S0378-1135(17)30163-3 [pii]
LID - 10.1016/j.vetmic.2017.04.016 [doi]
AB  - Virus neutralization (VN) responses range from narrowly focused antibodies with 
      only homologous neutralizing activity against the virus used for infection, to 
      antibodies that can neutralize both Type 1 and Type 2 viruses, referred to as 
      broadly neutralizing antibody (bnAb). Even though neutralizing epitopes are 
      likely distributed among several structural glycoproteins, this paper focuses on 
      the ectodomain region of GP5 as a model system for investigating the role for 
      neutralizing and non-neutralizing antibodies in protection and disease. Epitope B 
      within GP5 possesses several features common to broadly neutralizing epitopes. In 
      the proposed model, accessibility of antibody to Epitope B is blocked by 
      homologous neutralizing and non-neutralizing antibodies, which bind flanking 
      hypervariable domains. Additional mechanisms for blocking the accessibility of 
      bnAb include conformational alterations within the GP5-M heterodimer and glycan 
      shielding. This model explains how the continuous escape from homologous 
      neutralization provides a mechanism for persistence. The proposed mechanism for 
      immune evasion is not unique to PRRSV, but can be found in other persistent 
      viruses, such as hepatitis C virus (HCV).
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Popescu, Luca N
AU  - Popescu LN
AD  - Department of Diagnostic Medicine and Pathobiology, Kansas State University, 
      Manhattan, KS 66506, United States.
FAU - Trible, Benjamin R
AU  - Trible BR
AD  - Department of Diagnostic Medicine and Pathobiology, Kansas State University, 
      Manhattan, KS 66506, United States.
FAU - Chen, Nanhua
AU  - Chen N
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, 
      PR China.
FAU - Rowland, Raymond R R
AU  - Rowland RRR
AD  - Department of Diagnostic Medicine and Pathobiology, Kansas State University, 
      Manhattan, KS 66506, United States. Electronic address: browland@vet.k-state.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170429
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Epitopes)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (glycoprotein 5, PRRSV)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/*immunology
MH  - Epitopes/immunology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*genetics
MH  - Swine
MH  - Viral Envelope Proteins/*immunology
OTO - NOTNLM
OT  - Broadly neutralizing antibodies
OT  - HCV
OT  - Neutralizing epitopes
OT  - PRRS
EDAT- 2017/05/23 06:00
MHDA- 2018/04/04 06:00
CRDT- 2017/05/23 06:00
PHST- 2017/02/02 00:00 [received]
PHST- 2017/04/04 00:00 [revised]
PHST- 2017/04/20 00:00 [accepted]
PHST- 2017/05/23 06:00 [pubmed]
PHST- 2018/04/04 06:00 [medline]
PHST- 2017/05/23 06:00 [entrez]
AID - S0378-1135(17)30163-3 [pii]
AID - 10.1016/j.vetmic.2017.04.016 [doi]
PST - ppublish
SO  - Vet Microbiol. 2017 Sep;209:90-96. doi: 10.1016/j.vetmic.2017.04.016. Epub 2017 
      Apr 29.