PMID- 2853076
OWN - NLM
STAT- MEDLINE
DCOM- 19890427
LR  - 20190721
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 72
IP  - 3
DP  - 1988
TI  - The involvement of excitatory amino acid receptors within the prepiriform cortex 
      in pilocarpine-induced limbic seizures in rats.
PG  - 517-22
AB  - The prepiriform cortex (PPCx) shows high sensitivity to the epileptogenic action 
      of chemo-convulsants and to the protective action of the NMDA receptor 
      antagonist, 2-amino-7-phosphono-heptanoate (APH) against pilocarpine-induced 
      (motor) limbic seizures in rats. In this study the interaction between agonists 
      acting selectively on the three main excitatory amino acid receptor subtypes in 
      the PPCx and the muscarinic agonist, pilocarpine, within the PPCx have been 
      investigated. Kainate (KA) or quisqualate (QUIS) injected focally into the PPCx 
      (100 pmoles or 5 nmoles per side respectively) induced motor limbic seizures when 
      administered after a subconvulsant dose of pilocarpine (250 mg/kg, i.p.). KA, 100 
      pmoles injected into the same site in olfactory-bulboectomized rats (bulbectomy 
      results in protection against pilocarpine-induced seizures) also facilitated 
      seizures. However, activation of the NMDA receptor in the PPCx by focal injection 
      of NMDA (250 fmoles-10 nmoles) failed to produce seizures after a subconvulsant 
      dose of pilocarpine. Moreover NMDA in the same range of doses injected into the 
      PPCx protected rats against the seizures induced by a fully convulsant dose of 
      pilocarpine.
FAU - Millan, M H
AU  - Millan MH
AD  - Department of Neurology, Institute of Psychiatry, London, UK.
FAU - Patel, S
AU  - Patel S
FAU - Meldrum, B S
AU  - Meldrum BS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (Oxadiazoles)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/pharmacology
MH  - Cerebral Cortex/drug effects/physiology/*physiopathology
MH  - Kainic Acid/pharmacology
MH  - Male
MH  - N-Methylaspartate
MH  - Olfactory Bulb/*physiology
MH  - Oxadiazoles/pharmacology
MH  - Pilocarpine/*pharmacology
MH  - Quisqualic Acid
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, N-Methyl-D-Aspartate
MH  - Receptors, Neurotransmitter/drug effects/*physiology
MH  - Reference Values
MH  - Seizures/chemically induced/*physiopathology
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1007/BF00250597 [doi]
PST - ppublish
SO  - Exp Brain Res. 1988;72(3):517-22. doi: 10.1007/BF00250597.