PMID- 28531943
OWN - NLM
STAT- MEDLINE
DCOM- 20180322
LR  - 20180322
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 91
DP  - 2017 Jul
TI  - Recent trends in ZikV research: A step away from cure.
PG  - 1152-1159
LID - S0753-3322(17)31321-5 [pii]
LID - 10.1016/j.biopha.2017.05.045 [doi]
AB  - Zika virus (ZikV) is a member of the Flaviviridae virus family, genus Flavivirus 
      has emerged as a potential threat to human health worldwide. Consequences of 
      vertical infections includes microcephaly with brain and eye anomalies, and adult 
      infections includes Guillain-Barresyndrome (GBS), brain ischemia, myelitis and 
      meningoencephalitis. To develop a better treatment, many efforts are being made, 
      like drug-repurposing concept for FDA-approved drugs for antiviral activity are 
      screened against ZikV infection and emerging as a promising alternative to 
      expedite drug development and various vaccines like DNA, ZPIV, LAIV, mRNA and 
      AGS-v vaccines have been designed and in under clinical trial phases. Moreover, 
      few pharmacological agents like Mycophenolicacid, Niclosamide, PHA-690509, 
      Emricasan and Bortezomib are most potent anti-ZikV candidates and highly 
      effective single or combining treatment with these drugs. This article reviews 
      the ZikV illness, transmission patterns, pathophysiology of disease, global 
      efforts, challenges and the prospects for the development of vaccines and 
      antiviral agents.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Alam, Aftab
AU  - Alam A
AD  - Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, New 
      Delhi, India.
FAU - Imam, Nikhat
AU  - Imam N
AD  - Institute of Computer Science and Information Technology, Magadh University, 
      Bodhgaya, Bihar, India.
FAU - Farooqui, Anam
AU  - Farooqui A
AD  - Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, New 
      Delhi, India.
FAU - Ali, Shahnawaz
AU  - Ali S
AD  - Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, New 
      Delhi, India.
FAU - Malik, Md Zubbair
AU  - Malik MZ
AD  - Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, New 
      Delhi, India.
FAU - Ishrat, Romana
AU  - Ishrat R
AD  - Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, New 
      Delhi, India. Electronic address: rishrat@jmi.ac.in.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170517
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antiviral Agents)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/*pharmacology/*therapeutic use
MH  - Brain/drug effects
MH  - Humans
MH  - Viral Vaccines/pharmacology/therapeutic use
MH  - Zika Virus/*drug effects
MH  - Zika Virus Infection/*drug therapy
OTO - NOTNLM
OT  - AGS-v
OT  - DNA vaccination
OT  - FDA
OT  - GBS
OT  - LAIV
OT  - MPA DNA
OT  - Microcephaly
OT  - ZPIV
OT  - ZikV
EDAT- 2017/05/24 06:00
MHDA- 2018/03/23 06:00
CRDT- 2017/05/24 06:00
PHST- 2017/03/21 00:00 [received]
PHST- 2017/05/02 00:00 [revised]
PHST- 2017/05/09 00:00 [accepted]
PHST- 2017/05/24 06:00 [pubmed]
PHST- 2018/03/23 06:00 [medline]
PHST- 2017/05/24 06:00 [entrez]
AID - S0753-3322(17)31321-5 [pii]
AID - 10.1016/j.biopha.2017.05.045 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2017 Jul;91:1152-1159. doi: 10.1016/j.biopha.2017.05.045. 
      Epub 2017 May 17.