PMID- 28532014
OWN - NLM
STAT- MEDLINE
DCOM- 20180206
LR  - 20181202
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 77
DP  - 2017 Aug 1
TI  - Advanced review of graphene-based nanomaterials in drug delivery systems: 
      Synthesis, modification, toxicity and application.
PG  - 1363-1375
LID - S0928-4931(17)30263-1 [pii]
LID - 10.1016/j.msec.2017.03.196 [doi]
AB  - The discovery of graphene, a notable achievement in the field of novel carbon 
      nanomaterials, has triggered the worldwide exploration of the biomedical 
      applications of this material since 2004 because of its unique properties. The 
      two-dimensional planar structure, large surface area, chemical stability, 
      mechanical stability, and good biocompatibility of graphene are promising for 
      applications in drug delivery systems (DDSs). In this review, we briefly discuss 
      the characteristics, synthesis, and modification of graphene. We also investigate 
      its toxicity and its applications in DDSs, with several representative examples. 
      This review presents a comprehensive summary of graphene-based nanomaterials from 
      their characteristics to their synthesis and applications, as well as their in 
      vitro and in vivo evaluation in medicine. This paper provides a guiding strategy 
      for the selection of optimal approaches to the fabrication of nanocarriers that 
      are suitable for medical treatments and to controlling the toxicity within 
      therapeutic safety limits. The promising achievements made with graphene-based 
      nanomaterials indicate several possibilities for further biomedical research, as 
      well as theoretical and applied development.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Experiment Center for Teaching and Learning, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China; School of Pharmacy, Shanghai University 
      of Traditional Chinese Medicine, Shanghai 201203, China.
FAU - Wu, Zhuona
AU  - Wu Z
AD  - Experiment Center for Teaching and Learning, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China; School of Pharmacy, Shanghai University 
      of Traditional Chinese Medicine, Shanghai 201203, China.
FAU - Li, Ning
AU  - Li N
AD  - Division of Life Science, HKUST Shenzhen Research Institute, Shenzhen 518057, 
      China.
FAU - Pu, Yiqiong
AU  - Pu Y
AD  - Experiment Center for Teaching and Learning, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China.
FAU - Wang, Bing
AU  - Wang B
AD  - Experiment Center for Teaching and Learning, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China; School of Pharmacy, Shanghai University 
      of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: 
      annabel_cn@163.com.
FAU - Zhang, Tong
AU  - Zhang T
AD  - Experiment Center for Teaching and Learning, Shanghai University of Traditional 
      Chinese Medicine, Shanghai 201203, China; School of Pharmacy, Shanghai University 
      of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: 
      zhangtdmj@hotmail.com.
FAU - Tao, Jiansheng
AU  - Tao J
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 
      201203, China. Electronic address: taojs@sohu.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170323
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Biomedical Research
MH  - Drug Delivery Systems
MH  - Graphite
MH  - Humans
MH  - *Nanostructures
OTO - NOTNLM
OT  - Drug delivery system
OT  - Graphene
OT  - Modification
OT  - Nanomaterials
OT  - Toxicity
EDAT- 2017/05/24 06:00
MHDA- 2018/02/07 06:00
CRDT- 2017/05/24 06:00
PHST- 2017/01/21 00:00 [received]
PHST- 2017/03/21 00:00 [revised]
PHST- 2017/03/22 00:00 [accepted]
PHST- 2017/05/24 06:00 [entrez]
PHST- 2017/05/24 06:00 [pubmed]
PHST- 2018/02/07 06:00 [medline]
AID - S0928-4931(17)30263-1 [pii]
AID - 10.1016/j.msec.2017.03.196 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:1363-1375. doi: 
      10.1016/j.msec.2017.03.196. Epub 2017 Mar 23.