PMID- 28532792
OWN - NLM
STAT- MEDLINE
DCOM- 20180103
LR  - 20180103
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 204
DP  - 2017 May
TI  - Preparation for emergence of an Eastern European porcine reproductive and 
      respiratory syndrome virus (PRRSV) strain in Western Europe: Immunization with 
      modified live virus vaccines or a field strain confers partial protection.
PG  - 133-140
LID - S0378-1135(17)30193-1 [pii]
LID - 10.1016/j.vetmic.2017.04.021 [doi]
AB  - The porcine reproductive and respiratory syndrome virus (PRRSV) causes huge 
      economic losses for the swine industry worldwide. In the past several years, 
      highly pathogenic strains that lead to even greater losses have emerged. For the 
      Western European swine industry, one threat is the possible introduction of 
      Eastern European PRRSV strains (example Lena genotype 1.3) which were shown to be 
      more virulent than common Western resident strains under experimental conditions. 
      To prepare for the possible emergence of this strain in Western Europe, we 
      immunized piglets with a Western European PRRSV field strain (Finistere: Fini, 
      genotype 1.1), a new genotype 1 commercial modified live virus (MLV) vaccine 
      (MLV1) or a genotype 2 commercial MLV vaccine (MLV2) to evaluate and compare the 
      level of protection that these strains conferred upon challenge with the Lena 
      strain 4 weeks later. Results show that immunization with Fini, MLV1 or MLV2 
      strains shortened the Lena-induced hyperthermia. In the Fini group, a positive 
      effect was also demonstrated in growth performance. The level of Lena viremia was 
      reduced for all immunized groups (significantly so for Fini and MLV2). This 
      reduction in Lena viremia was correlated with the level of Lena-specific 
      IFNgamma-secreting cells. In conclusion, we showed that a commercial MLV vaccine of 
      genotype 1 or 2, as well as a field strain of genotype 1.1 may provide partial 
      clinical and virological protection upon challenge with the Lena strain. The 
      cross-protection induced by these immunizing strains was not related with the 
      level of genetic similarity to the Lena strain. The slightly higher level of 
      protection established with the field strain is attributed to a better 
      cell-mediated immune response.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Renson, P
AU  - Renson P
AD  - Agence Nationale de Securite Sanitaire Alimentation Environnement Travail 
      (Anses), Unite Virologie Immunologie Porcines, BP 53, 22440 Ploufragan, France; 
      Union des Groupements de Producteurs de Viande de Bretagne (UGPVB), 104 rue 
      Eugene Pottier, 35065 Rennes, France; Universite Bretagne Loire, France.
FAU - Fablet, C
AU  - Fablet C
AD  - Anses, Unite Epidemiologie et Bien-etre Porcins, BP 53, 22440 Ploufragan, France; 
      Universite Bretagne Loire, France.
FAU - Le Dimna, M
AU  - Le Dimna M
AD  - Agence Nationale de Securite Sanitaire Alimentation Environnement Travail 
      (Anses), Unite Virologie Immunologie Porcines, BP 53, 22440 Ploufragan, France; 
      Universite Bretagne Loire, France.
FAU - Mahe, S
AU  - Mahe S
AD  - Agence Nationale de Securite Sanitaire Alimentation Environnement Travail 
      (Anses), Unite Virologie Immunologie Porcines, BP 53, 22440 Ploufragan, France; 
      Universite Bretagne Loire, France.
FAU - Touzain, F
AU  - Touzain F
AD  - Anses, Unite Genetique Virale et Biosecurite, BP 53, 22440 Ploufragan, France; 
      Universite Bretagne Loire, France.
FAU - Blanchard, Y
AU  - Blanchard Y
AD  - Anses, Unite Genetique Virale et Biosecurite, BP 53, 22440 Ploufragan, France; 
      Universite Bretagne Loire, France.
FAU - Paboeuf, F
AU  - Paboeuf F
AD  - Anses, Service de Production de Porcs Assainis et Experimental, BP 53, 22440 
      Ploufragan, France; Universite Bretagne Loire, France.
FAU - Rose, N
AU  - Rose N
AD  - Anses, Unite Epidemiologie et Bien-etre Porcins, BP 53, 22440 Ploufragan, France; 
      Universite Bretagne Loire, France.
FAU - Bourry, O
AU  - Bourry O
AD  - Agence Nationale de Securite Sanitaire Alimentation Environnement Travail 
      (Anses), Unite Virologie Immunologie Porcines, BP 53, 22440 Ploufragan, France; 
      Universite Bretagne Loire, France. Electronic address: olivier.bourry@anses.fr.
LA  - eng
PT  - Journal Article
DEP - 20170427
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Communicable Diseases, Emerging/epidemiology/*veterinary/virology
MH  - Europe/epidemiology
MH  - Immunization/*veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/prevention & 
      control/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*genetics
MH  - Swine
MH  - Viral Vaccines/*immunology
OTO - NOTNLM
OT  - Cross-protection
OT  - Genotype 1.3
OT  - Heterologous
OT  - IFNgamma response
OT  - PRRS
OT  - Vaccine
EDAT- 2017/05/24 06:00
MHDA- 2018/01/04 06:00
CRDT- 2017/05/24 06:00
PHST- 2017/02/10 00:00 [received]
PHST- 2017/04/18 00:00 [revised]
PHST- 2017/04/21 00:00 [accepted]
PHST- 2017/05/24 06:00 [entrez]
PHST- 2017/05/24 06:00 [pubmed]
PHST- 2018/01/04 06:00 [medline]
AID - S0378-1135(17)30193-1 [pii]
AID - 10.1016/j.vetmic.2017.04.021 [doi]
PST - ppublish
SO  - Vet Microbiol. 2017 May;204:133-140. doi: 10.1016/j.vetmic.2017.04.021. Epub 2017 
      Apr 27.