PMID- 28533100
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20180727
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 27
IP  - 4
DP  - 2018 Apr
TI  - Effects of Remote Ischaemic Conditioning on Heart Rate Variability and Cardiac 
      Function in Patients With Mild Ischaemic Heart Failure.
PG  - 477-483
LID - S1443-9506(17)30335-9 [pii]
LID - 10.1016/j.hlc.2017.03.164 [doi]
AB  - BACKGROUND: Cardioprotective effects of remote ischaemic conditioning (RIC) in 
      the setting of ischaemic heart disease have been shown recently. But the effects 
      of RIC on heart rate variability (HRV) and cardiac function in patients with 
      stable ischaemic heart failure (IHF) are still unknown. METHODS: Fifty patients 
      with stable IHF were enrolled and randomly divided into RIC group and control 
      group. Remote ischaemic conditioning treatment was performed twice a day for 6 
      weeks. A remote is chaemic conditioning protocol consisted of 4x5min 
      inflation/deflation of the blood pressure cuff applied in the upper arm to create 
      intermittent arm ischaemia. B-type natriuretic peptide (BNP), left ventricular 
      ejection fraction (LVEF), 24-hour ambulatory electrocardiogram, and 6-minute walk 
      distance (6MWD) were all assessed in two groups. RESULTS: Forty-seven patients 
      completed the study. Remote ischaemic conditioning was well-tolerated by patients 
      in the RIC group after 6 weeks treatment and LVEF showed a significant increase, 
      from 39.2% to 43.4% (p<0.001), as well as decreased BNP, increased 6MWD and HRV, 
      but this was not observed in the control group. In addition, the patients treated 
      with RIC also showed improved NYHA class, LVEF, 6MWD, BNP level and HRV compared 
      to control group. CONCLUSIONS: This study suggests that a 6-week course of RIC 
      treatment could improve cardiac function and HRV in patients with mild and stable 
      IHF, supporting widespread use of RIC in the daily lives of these patients.
CI  - Copyright (c) 2017 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      Published by Elsevier B.V. All rights reserved.
FAU - Chen, Long
AU  - Chen L
AD  - Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China. Electronic address: longchen.crown@163.com.
FAU - Zhou, Qianxing
AU  - Zhou Q
AD  - Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
FAU - Jin, Hong
AU  - Jin H
AD  - Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
FAU - Zhu, Kongbo
AU  - Zhu K
AD  - Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
FAU - Zhi, Hong
AU  - Zhi H
AD  - Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
FAU - Chen, Zhongpu
AU  - Chen Z
AD  - Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
FAU - Ma, Genshan
AU  - Ma G
AD  - Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170503
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
SB  - IM
MH  - Aged
MH  - Cardiac Volume/*physiology
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/diagnosis/physiopathology/*therapy
MH  - Heart Rate/*physiology
MH  - Heart Ventricles/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Ischemic Preconditioning, Myocardial/*methods
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Stroke Volume/*physiology
MH  - Telemedicine/*methods
MH  - Ventricular Function, Left/physiology
OTO - NOTNLM
OT  - Heart failure
OT  - Heart rate variability
OT  - Ischaemic heart disease
OT  - Remote ischaemic conditioning
EDAT- 2017/05/24 06:00
MHDA- 2018/07/28 06:00
CRDT- 2017/05/24 06:00
PHST- 2016/04/25 00:00 [received]
PHST- 2017/01/21 00:00 [revised]
PHST- 2017/03/29 00:00 [accepted]
PHST- 2017/05/24 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/05/24 06:00 [entrez]
AID - S1443-9506(17)30335-9 [pii]
AID - 10.1016/j.hlc.2017.03.164 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2018 Apr;27(4):477-483. doi: 10.1016/j.hlc.2017.03.164. Epub 
      2017 May 3.