PMID- 28533117
OWN - NLM
STAT- MEDLINE
DCOM- 20180508
LR  - 20220129
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 156
DP  - 2017 Aug 1
TI  - Activation induced changes in GABA: Functional MRS at 7T with MEGA-sLASER.
PG  - 207-213
LID - S1053-8119(17)30443-3 [pii]
LID - 10.1016/j.neuroimage.2017.05.044 [doi]
AB  - Functional magnetic resonance spectroscopy (fMRS) has been used to assess the 
      dynamic metabolic responses of the brain to a physiological stimulus 
      non-invasively. However, only limited information on the dynamic functional 
      response of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter 
      in the brain, is available. We aimed to measure the activation-induced changes in 
      GABA unambiguously using a spectral editing method, instead of the conventional 
      direct detection techniques used in previous fMRS studies. The 
      Mescher-Garwood-semi-localised by adiabatic selective refocusing (MEGA-sLASER) 
      sequence was developed at 7T to obtain the time course of GABA concentration 
      without macromolecular contamination. A significant decrease (-12+/-5%) in the GABA 
      to total creatine ratio (GABA/tCr) was observed in the motor cortex during a 
      period of 10min of hand-clenching, compared to an initial baseline level 
      (GABA/tCr =0.11+/-0.02) at rest. An increase in the Glx (glutamate and glutamine) 
      to tCr ratio was also found, which is in agreement with previous findings. In 
      contrast, no significant changes in NAA/tCr and tCr were detected. With 
      consistent and highly efficient editing performance for GABA detection and the 
      advantage of visually identifying GABA resonances in the spectra, MEGA-sLASER is 
      demonstrated to be an effective method for studying of dynamic changes in GABA at 
      7T.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Chen, Chen
AU  - Chen C
AD  - Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United 
      Kingdom. Electronic address: chen.chen@nottingham.ac.uk.
FAU - Sigurdsson, Hilmar P
AU  - Sigurdsson HP
AD  - School of Psychology, University of Nottingham, Nottingham, United Kingdom.
FAU - Pepes, Sophia E
AU  - Pepes SE
AD  - School of Psychology, University of Nottingham, Nottingham, United Kingdom.
FAU - Auer, Dorothee P
AU  - Auer DP
AD  - Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United 
      Kingdom; School of Medicine, University of Nottingham, Nottingham, United 
      Kingdom.
FAU - Morris, Peter G
AU  - Morris PG
AD  - Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United 
      Kingdom.
FAU - Morgan, Paul S
AU  - Morgan PS
AD  - School of Medicine, University of Nottingham, Nottingham, United Kingdom.
FAU - Gowland, Penny A
AU  - Gowland PA
AD  - Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United 
      Kingdom.
FAU - Jackson, Stephen R
AU  - Jackson SR
AD  - School of Psychology, University of Nottingham, Nottingham, United Kingdom.
LA  - eng
GR  - G0901321/MRC_/Medical Research Council/United Kingdom
GR  - MR/M009122/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170519
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Adult
MH  - Brain/*metabolism
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Neuroimaging/*methods
MH  - Young Adult
MH  - gamma-Aminobutyric Acid/*analysis/metabolism
OTO - NOTNLM
OT  - 7T
OT  - Functional MRS
OT  - GABA
OT  - MEGA editing
OT  - Motor cortex
EDAT- 2017/05/24 06:00
MHDA- 2018/05/09 06:00
CRDT- 2017/05/24 06:00
PHST- 2017/03/22 00:00 [received]
PHST- 2017/05/16 00:00 [revised]
PHST- 2017/05/19 00:00 [accepted]
PHST- 2017/05/24 06:00 [pubmed]
PHST- 2018/05/09 06:00 [medline]
PHST- 2017/05/24 06:00 [entrez]
AID - S1053-8119(17)30443-3 [pii]
AID - 10.1016/j.neuroimage.2017.05.044 [doi]
PST - ppublish
SO  - Neuroimage. 2017 Aug 1;156:207-213. doi: 10.1016/j.neuroimage.2017.05.044. Epub 
      2017 May 19.