PMID- 28534294 OWN - NLM STAT- MEDLINE DCOM- 20180104 LR - 20181202 IS - 1535-1645 (Electronic) IS - 1523-3812 (Linking) VI - 19 IP - 7 DP - 2017 Jul TI - Brain-Derived Neurotrophic Factor Expression in Individuals With Schizophrenia and Healthy Aging: Testing the Accelerated Aging Hypothesis of Schizophrenia. PG - 36 LID - 10.1007/s11920-017-0794-6 [doi] AB - PURPOSE OF REVIEW: Schizophrenia has been hypothesized to be a syndrome of accelerated aging. Brain plasticity is vulnerable to the normal aging process and affected in schizophrenia: brain-derived neurotrophic factor (BDNF) is an important neuroplasticity molecule. The present review explores the accelerated aging hypothesis of schizophrenia by comparing changes in BDNF expression in schizophrenia with aging-associated changes. RECENT FINDINGS: Individuals with schizophrenia show patterns of increased overall mortality, metabolic abnormalities, and cognitive decline normally observed later in life in the healthy population. An overall decrease is observed in BDNF expression in schizophrenia compared to healthy controls and in older individuals compared to a younger cohort. There is a marked decrease in BDNF levels in the frontal regions and in the periphery among older individuals and those with schizophrenia; however, data for BDNF expression in the occipital, parietal, and temporal cortices and the hippocampus is inconclusive. Accelerated aging hypothesis is supported based on frontal regions and peripheral studies; however, further studies are needed in other brain regions. FAU - Islam, Farhana AU - Islam F AD - Human Biology Department, University of Toronto, 300 Huron Street, Toronto, ON, M5S 3J6, Canada. FAU - Mulsant, Benoit H AU - Mulsant BH AD - Division of Geriatric Psychiatry, Department of Psychiatry, University of Toronto, Toronto, ON, Canada. AD - Division of Geriatric Psychiatry, Centre for Addiction and Mental Health, 80 Workman Way, 6th floor, Room 6312, Toronto, ON, M6J1H4, Canada. FAU - Voineskos, Aristotle N AU - Voineskos AN AD - Division of Geriatric Psychiatry, Department of Psychiatry, University of Toronto, Toronto, ON, Canada. AD - Division of Geriatric Psychiatry, Centre for Addiction and Mental Health, 80 Workman Way, 6th floor, Room 6312, Toronto, ON, M6J1H4, Canada. FAU - Rajji, Tarek K AU - Rajji TK AD - Division of Geriatric Psychiatry, Department of Psychiatry, University of Toronto, Toronto, ON, Canada. tarek.rajji@camh.ca. AD - Division of Geriatric Psychiatry, Centre for Addiction and Mental Health, 80 Workman Way, 6th floor, Room 6312, Toronto, ON, M6J1H4, Canada. tarek.rajji@camh.ca. LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Psychiatry Rep JT - Current psychiatry reports JID - 100888960 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - *Aging MH - Brain/*metabolism MH - Brain-Derived Neurotrophic Factor/genetics/*metabolism MH - *Healthy Aging MH - Humans MH - Male MH - Schizophrenia/genetics/*metabolism OTO - NOTNLM OT - Accelerated aging hypothesis OT - Aging OT - BDNF OT - Brain-derived neurotrophic factor OT - Neurodevelopment OT - Neuroplasticity OT - Schizophrenia EDAT- 2017/05/24 06:00 MHDA- 2018/01/05 06:00 CRDT- 2017/05/24 06:00 PHST- 2017/05/24 06:00 [entrez] PHST- 2017/05/24 06:00 [pubmed] PHST- 2018/01/05 06:00 [medline] AID - 10.1007/s11920-017-0794-6 [pii] AID - 10.1007/s11920-017-0794-6 [doi] PST - ppublish SO - Curr Psychiatry Rep. 2017 Jul;19(7):36. doi: 10.1007/s11920-017-0794-6.