PMID- 28534557
OWN - NLM
STAT- MEDLINE
DCOM- 20180516
LR  - 20180516
IS  - 2340-3527 (Electronic)
IS  - 1137-6627 (Linking)
VI  - 40
IP  - 1
DP  - 2017 Apr 30
TI  - [Circuit life span of continuous renal replacement therapy in critically ill 
      patients with or without conventional anticoa-gulation: an observational 
      prospective study].
PG  - 77-84
LID - 10.23938/ASSN.0008 [doi]
AB  - BACKGROUND: The aim of this study was to describe the efficacy, security and 
      viability of an anticoagulation system with continuous infusion of unfractionated 
      heparin (UFH) versus one without any type of anticoagulant using 0.9% 
      physiological saline washings, in critically ill patients with continuous renal 
      replacement therapy (CRRT) and different risks of bleeding. METHODS: From October 
      2013 to April 2015 we conducted an observational prospective study in the 
      intensive care unit (ICU). Sixty-one patients with acute kidney injury (AKI) and 
      requiring CRRT were included, with 122 filters. Patients and filters were divided 
      in two groups: anticoagulated (AC) and not anticoagulated (No AC). The main 
      outcome measure was filter life span. Different analytical parameters were also 
      collected at the beginning of treatment and at the moment of circuit coagulation 
      Results. The number of patients was similar in both groups. We did not find 
      statistically significant differences between the two groups in filter life span 
      (30.5 hours AC vs 34.9 hours No AC). Patients with increased morbidity (severe 
      thrombocytopenia, coagulopathy, etc.) were included in the group that did not 
      received anticoagulation but saline flushes. CONCLUSIONS: CRRT without 
      anticoagulation with saline flushes is a viable, safe and effective strategy in 
      critically ill patients with high risk of bleeding. This approach achieves a 
      circuit life span similar to that observed in anticoagulated patients with UFH; 
      avoiding the risks and costs associated with anticoagulation.
FAU - Sanz, M
AU  - Sanz M
AD  - . msganuza.1@alumni.unav.es.
FAU - Hidalgo, F
AU  - Hidalgo F
FAU - Garcia-Fernandez, N
AU  - Garcia-Fernandez N
LA  - spa
PT  - Journal Article
PT  - Observational Study
TT  - Supervivencia de circuitos de tecnicas de depuracion extrarrenal continua en 
      pacientes criticos con o sin anticoagulacion convencional: estudio observacional 
      prospectivo.
DEP - 20170430
PL  - Spain
TA  - An Sist Sanit Navar
JT  - Anales del sistema sanitario de Navarra
JID - 9710381
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
CIN - An Sist Sanit Navar. 2018 Apr 30;41(1):131-136. PMID: 29465086
CIN - An Sist Sanit Navar. 2018 Apr 30;41(1):135-136. PMID: 29582854
MH  - Acute Kidney Injury/*therapy
MH  - Anticoagulants/*therapeutic use
MH  - Critical Illness
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Renal Replacement Therapy
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Anticoagulation. Critical patients. Extrarenal depuration techniques. Heparin. 
      Saline solution.
EDAT- 2017/05/24 06:00
MHDA- 2018/05/17 06:00
CRDT- 2017/05/24 06:00
PHST- 2017/05/24 06:00 [entrez]
PHST- 2017/05/24 06:00 [pubmed]
PHST- 2018/05/17 06:00 [medline]
AID - 10.23938/ASSN.0008 [doi]
PST - epublish
SO  - An Sist Sanit Navar. 2017 Apr 30;40(1):77-84. doi: 10.23938/ASSN.0008.