PMID- 28535046
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20170626
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 65
IP  - 23
DP  - 2017 Jun 14
TI  - Inhibitory Effect of Piceatannol on TNF-alpha-Mediated Inflammation and Insulin 
      Resistance in 3T3-L1 Adipocytes.
PG  - 4634-4641
LID - 10.1021/acs.jafc.7b01567 [doi]
AB  - Piceatannol, a bioactive component in grape and blueberry, was examined for its 
      potential in decreasing the inflammatory activities in adipocytes using a 
      cocultured adipocyte and macrophage system, and suppressing tumor necrosis 
      factor-alpha (TNF-alpha)-mediated inflammation and the related insulin resistance using a 
      3T3-L1 adipocyte model. Piceatannol at 10 muM significantly reduced the release of 
      inflammatory cytokines of TNF-alpha and monocyte chemoattractant protein-1 (MCP-1) by 
      19 and 31% in the cocultured system, respectively. Pretreatment with piceatannol 
      also inhibited TNF-alpha-induced expression of interleukin-6 (IL-6) and MCP-1 at both 
      mRNA and protein levels in the 3T3-L1 adipocytes. Piceatannol also partially 
      improved the malfunction of insulin-stimulated glucose uptake, which was reduced 
      by TNF-alpha in 3T3-L1 adipocytes. Furthermore, the inhibitions were mediated by 
      significant blocking of IkappaBalpha phosphorylation and nuclear factor-kappaB (NF-kappaB) 
      activation through suppressing nuclear translocation of NF-kappaB p65 along with 
      c-Jun N-terminal kinase (JNK)-mitogen activated protein kinase (MAPK) activation. 
      In addition, the Akt-dependent forkhead box O1 (FoxO1) signaling pathway was 
      involved in the restoration of insulin-stimulated glucose uptake through 
      suppressing the down-regulation of phosphorylation of Akt and FoxO1 expressions. 
      These results suggested the potential of piceatannol in improving chronic 
      inflammatory condition and insulin sensitivity in obese adipose tissues.
FAU - Li, Yanfang
AU  - Li Y
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing 
      Technology & Business University , Beijing 100048, China.
AD  - Institute of Food and Nutraceutical Science, School of Agriculture and Biology, 
      Shanghai Jiao Tong University , Shanghai 200240, China.
FAU - Yang, Puyu
AU  - Yang P
AD  - Institute of Food and Nutraceutical Science, School of Agriculture and Biology, 
      Shanghai Jiao Tong University , Shanghai 200240, China.
FAU - Chang, Qimeng
AU  - Chang Q
AD  - Department of Surgery, Fudan University Minhang Hospital , Shanghai 201199, 
      China.
FAU - Wang, Jing
AU  - Wang J
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing 
      Technology & Business University , Beijing 100048, China.
FAU - Liu, Jie
AU  - Liu J
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing 
      Technology & Business University , Beijing 100048, China.
FAU - Lv, Yuan
AU  - Lv Y
AD  - Institute of Food and Nutraceutical Science, School of Agriculture and Biology, 
      Shanghai Jiao Tong University , Shanghai 200240, China.
FAU - Wang, Thomas T Y
AU  - Wang TTY
AD  - Diet, Genomics, and Immunology Laboratory, Agricultural Research Service (ARS), 
      U.S. Department of Agriculture , Beltsville, Maryland 20705, United States.
FAU - Gao, Boyan
AU  - Gao B
AD  - Department of Nutrition and Food Science, University of Maryland , College Park, 
      Maryland 20742, United States.
FAU - Zhang, Yaqiong
AU  - Zhang Y
AD  - Institute of Food and Nutraceutical Science, School of Agriculture and Biology, 
      Shanghai Jiao Tong University , Shanghai 200240, China.
FAU - Yu, Liangli Lucy
AU  - Yu LL
AUID- ORCID: 0000-0001-6497-0864
AD  - Department of Nutrition and Food Science, University of Maryland , College Park, 
      Maryland 20742, United States.
LA  - eng
PT  - Journal Article
DEP - 20170605
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Forkhead Box Protein O1)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Plant Extracts)
RN  - 0 (Stilbenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 6KS3LS0D4F (3,3',4,5'-tetrahydroxystilbene)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/*drug effects/metabolism
MH  - Animals
MH  - Chemokine CCL2/genetics/metabolism
MH  - Forkhead Box Protein O1/genetics/metabolism
MH  - Humans
MH  - Inflammation/*drug therapy/genetics/metabolism
MH  - Insulin/metabolism
MH  - *Insulin Resistance
MH  - Interleukin-6/genetics/metabolism
MH  - Mice
MH  - Phosphorylation
MH  - Plant Extracts/*pharmacology
MH  - Stilbenes/*pharmacology
MH  - Tumor Necrosis Factor-alpha/*immunology
OTO - NOTNLM
OT  - 3T3-L1 adipocytes
OT  - TNF-alpha
OT  - inflammation
OT  - insulin resistant
OT  - piceatannol
EDAT- 2017/05/24 06:00
MHDA- 2017/06/27 06:00
CRDT- 2017/05/24 06:00
PHST- 2017/05/24 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2017/05/24 06:00 [entrez]
AID - 10.1021/acs.jafc.7b01567 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2017 Jun 14;65(23):4634-4641. doi: 10.1021/acs.jafc.7b01567. 
      Epub 2017 Jun 5.