PMID- 28538192
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20180205
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 92
DP  - 2017 Aug
TI  - Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: 
      Possible suppression of toll-like receptor 4-mediated signaling.
PG  - 157-167
LID - S0753-3322(17)31017-X [pii]
LID - 10.1016/j.biopha.2017.05.036 [doi]
AB  - The hepatic anti-inflammatory potential of hexane extracts of Dioscorea batatas 
      Decne edible part (EDH-1e) and bark (EDH-2b) were investigated in Western-type 
      diet-fed apolipoprotein E null [ApoE (-/-)] mice and HepG2 cells. EDH-1e and 
      EDH-2b suppressed the increased levels of tumor necrosis factor alpha (TNF-alpha), 
      interleukin (IL)-6, transforming growth factor beta 1 (TGF-beta1), vascular cell 
      adhesion protein 1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1), and 
      reduced infiltration of monocytes into liver tissue. The protein levels of 
      Toll-like receptor 4 (TLR4) were also downregulated by EDH-1e and EDH-2b 
      treatment as were the levels of activator protein 1 (AP-1), c-fos, and c-jun in 
      the livers from Western-type diet-fed ApoE (-/-) mice and in 
      lipopolysaccharide-stimulated HepG2 cells. Taken together, EDH-1e and EDH-2b 
      attenuated hepatic inflammation and fibrosis via suppression of the 
      TLR4-AP1-mediated signaling pathway.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Koo, Hyun Jung
AU  - Koo HJ
AD  - Department of Medicinal and Industrial Crops, Korea National College of 
      Agriculture and Fisheries, Jeonju 54874, Republic of Korea.
FAU - Lee, SungRyul
AU  - Lee S
AD  - Department of Integrated Biomedical Science, Cardiovascular and Metabolic Disease 
      Center, College of Medicine, Inje University, Busan, 47392, Republic of Korea.
FAU - Chang, Kwang Jin
AU  - Chang KJ
AD  - Department of Medicinal and Industrial Crops, Korea National College of 
      Agriculture and Fisheries, Jeonju 54874, Republic of Korea.
FAU - Sohn, Eunsoo
AU  - Sohn E
AD  - Department of Scientometric Research, Korea Institute of Science and Technology 
      Information, Seoul, Republic of Korea.
FAU - Sohn, Eun-Hwa
AU  - Sohn EH
AD  - Department of Herbal Medicine Resources, Kangwon National University, Samcheok 
      25913, Republic of Korea. Electronic address: ehson@kangwon.ac.kr.
FAU - Kang, Se Chan
AU  - Kang SC
AD  - Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung 
      Hee University, Yongin 17104, Republic of Korea. Electronic address: 
      sckang@khu.ac.kr.
FAU - Pyo, Suhkneung
AU  - Pyo S
AD  - School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, 16419, Republic 
      of Korea. Electronic address: snpyo@skku.edu.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170521
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Hexanes)
RN  - 0 (Plant Extracts)
RN  - 0 (Solvents)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Transcription Factor AP-1)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Diet, Western/adverse effects
MH  - Dioscorea/*chemistry
MH  - Ethnopharmacology
MH  - Hep G2 Cells
MH  - Hepatocytes/*drug effects/immunology/metabolism/pathology
MH  - Hexanes/chemistry
MH  - Humans
MH  - Male
MH  - Medicine, Korean Traditional
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Monocytes/drug effects/immunology/metabolism/pathology
MH  - Non-alcoholic Fatty Liver Disease/*drug therapy/immunology/metabolism/pathology
MH  - Plant Bark/chemistry
MH  - Plant Extracts/*therapeutic use
MH  - Rhizome/chemistry
MH  - Signal Transduction/*drug effects
MH  - Solvents/chemistry
MH  - Toll-Like Receptor 4/*antagonists & inhibitors/metabolism
MH  - Transcription Factor AP-1/antagonists & inhibitors/metabolism
OTO - NOTNLM
OT  - Activator protein 1
OT  - ApoE
OT  - Dioscorea batatas Decne
OT  - HepG2
OT  - Inflammation
OT  - Toll-like receptor 4
EDAT- 2017/05/26 06:00
MHDA- 2018/02/06 06:00
CRDT- 2017/05/25 06:00
PHST- 2017/03/06 00:00 [received]
PHST- 2017/05/03 00:00 [revised]
PHST- 2017/05/08 00:00 [accepted]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
PHST- 2017/05/25 06:00 [entrez]
AID - S0753-3322(17)31017-X [pii]
AID - 10.1016/j.biopha.2017.05.036 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2017 Aug;92:157-167. doi: 10.1016/j.biopha.2017.05.036. Epub 
      2017 May 21.