PMID- 28538414
OWN - NLM
STAT- MEDLINE
DCOM- 20170629
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 21
DP  - 2017 May
TI  - Clinical predictors for the manifestation of late gadolinium enhancement after 
      acute myocardial infarction.
PG  - e7004
LID - 10.1097/MD.0000000000007004 [doi]
LID - e7004
AB  - Despite prompt revascularization, some patients with acute myocardial infarction 
      (AMI) develop myocardial scars, which can be visualized by late gadolinium 
      enhancement (LGE) in cardiovascular magnetic resonance imaging (CMR). Our goal 
      was to identify angiographic findings that were predictive for scar development 
      in patients after reperfused AMI.We examined 136 patients after first ST-elevated 
      myocardial infarction by CMR after a median of 4 days (range: 2-7). Patients with 
      manifestation of LGE were matched to patients without LGE by means of age and 
      gender. Clinical follow-up with a combined primary endpoint including myocardial 
      reinfarction, congestive heart failure, stroke, death and development of left 
      ventricular thrombus was reported after 24 months.Patients with manifestation of 
      LGE had a significant longer time of symptom-to-intervention, a higher prevalence 
      of anterior AMI, and more proximal culprit lesions. Furthermore, left ventricular 
      ejection fraction was significantly decreased, and peak values of infarct markers 
      were significantly higher in these patients. Preinterventional thrombolysis in 
      myocardial infarction-0-flow was significantly more frequent in patients with LGE 
      manifestation. The presence of 3-vessel disease (odds ratio 53.99, 95% confidence 
      interval 8.22-354.63, P <.001), a proximal culprit lesion, and high creatine 
      kinase myocardial band (CK-MB) values were identified as independent predictors 
      of LGE. Follow-up demonstrated a higher incidence of clinical events in the group 
      with LGE, with the most common cause of heart failure (38.2% vs 7.4%, 
      P <.001).The extent of angiographic findings in AMI plays a major role in the 
      manifestation of LGE. The presence of a multivessel disease, a proximal culprit 
      lesion, and high values of CK-MB are strong independent predictors for LGE 
      manifestation.
FAU - Abanador-Kamper, Nadine
AU  - Abanador-Kamper N
AD  - Department of Cardiology Center for Clinical Medicine (ZFKM) Department of 
      Diagnostic and Interventional Radiology, HELIOS University Hospital Wuppertal, 
      University Witten/Herdecke, Germany.
FAU - Kamper, Lars
AU  - Kamper L
FAU - Vorpahl, Marc
AU  - Vorpahl M
FAU - Brinkmann, Hilmar
AU  - Brinkmann H
FAU - Karamani, Vasiliki
AU  - Karamani V
FAU - Haage, Patrick
AU  - Haage P
FAU - Seyfarth, Melchior
AU  - Seyfarth M
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Contrast Media
MH  - *Coronary Angiography
MH  - Female
MH  - Follow-Up Studies
MH  - *Gadolinium
MH  - Humans
MH  - *Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*diagnostic imaging/mortality
MH  - Prognosis
MH  - Young Adult
PMC - PMC5457894
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2017/05/26 06:00
MHDA- 2017/07/01 06:00
PMCR- 2017/05/26
CRDT- 2017/05/25 06:00
PHST- 2017/05/25 06:00 [entrez]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2017/05/26 00:00 [pmc-release]
AID - 00005792-201705260-00055 [pii]
AID - MD-D-17-01691 [pii]
AID - 10.1097/MD.0000000000007004 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 May;96(21):e7004. doi: 10.1097/MD.0000000000007004.