PMID- 28538519 OWN - NLM STAT- MEDLINE DCOM- 20180405 LR - 20181113 IS - 1473-558X (Electronic) IS - 0959-4965 (Print) IS - 0959-4965 (Linking) VI - 28 IP - 11 DP - 2017 Aug 2 TI - Expression of brain-derived neurotrophic factors, neurotrophin-3, and neurotrophin-4 in the nucleus accumbens during heroin dependency and withdrawal. PG - 654-660 LID - 10.1097/WNR.0000000000000810 [doi] AB - Neurotrophins, brain-derived neurotrophic factors (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), have been implicated in the modulation of heroin dependency. This study was designed to explore the expression alterations of BDNF, NT-3, and NT-4 in the context of heroin dependence and withdrawal in the rat nucleus accumbens (NAc). Heroin dependence was induced by a progressive intraperitoneal treatment of heroin. The results showed that the expression levels of BDNF and NT-4 were significantly decreased in the NAc of rats with heroin addiction in comparison with the control group, whereas there was a significant increase in BDNF and NT-4 expressions in the groups of rats with both naloxone-induced and spontaneous withdrawal. Moreover, NT-3 expression was markedly increased in the NAc of rats with heroin addiction and spontaneous withdrawal in comparison with the control group, but decreased in the NAc of rats with naloxone-induced withdrawal. These results indicated that chronic administration of heroin results in the alterations of BDNF, NT-3, and NT-4 expressions in the rat NAc. BDNF, NT-3, and NT-4 may play a critical role in the development of heroin dependency and withdrawal. FAU - Li, Yixin AU - Li Y AD - Department of Histology and Embryology, Guizhou Medical University, Guiyang, China. FAU - Xia, Baijuan AU - Xia B FAU - Li, Rongrong AU - Li R FAU - Yin, Dan AU - Yin D FAU - Wang, Yanlin AU - Wang Y FAU - Liang, Wenmei AU - Liang W LA - eng PT - Journal Article PL - England TA - Neuroreport JT - Neuroreport JID - 9100935 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Neurotrophin 3) RN - 0 (RNA, Messenger) RN - 70D95007SX (Heroin) RN - P658DCA9XD (neurotrophin 4) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Heroin/*toxicity MH - Nerve Growth Factors/*metabolism MH - Neurotrophin 3/*metabolism MH - RNA, Messenger/metabolism MH - Rats, Sprague-Dawley MH - Substance Withdrawal Syndrome/*metabolism PMC - PMC5491224 EDAT- 2017/05/26 06:00 MHDA- 2018/04/06 06:00 PMCR- 2017/06/29 CRDT- 2017/05/25 06:00 PHST- 2017/05/26 06:00 [pubmed] PHST- 2018/04/06 06:00 [medline] PHST- 2017/05/25 06:00 [entrez] PHST- 2017/06/29 00:00 [pmc-release] AID - 10.1097/WNR.0000000000000810 [doi] PST - ppublish SO - Neuroreport. 2017 Aug 2;28(11):654-660. doi: 10.1097/WNR.0000000000000810.