PMID- 28539110 OWN - NLM STAT- MEDLINE DCOM- 20170901 LR - 20181113 IS - 1756-994X (Electronic) IS - 1756-994X (Linking) VI - 9 IP - 1 DP - 2017 May 24 TI - Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance. PG - 44 LID - 10.1186/s13073-017-0439-8 [doi] LID - 44 AB - Advances in mass spectrometry have allowed the high-throughput quantitative identification of human leukocyte antigen (HLA) class I ligands, and recent studies have reported on the breadth and diversity of the HLA class I immunopeptidome. These findings have far-reaching implications for immunosurveillance by T cells and translational value for immunotherapy. FAU - Melief, Cornelis J M AU - Melief CJM AD - ISA Pharmaceuticals, J.H. Oortweg 19, 2333 CH, Leiden, The Netherlands. melief@isa-pharma.com. FAU - Kessler, Jan H AU - Kessler JH AD - ISA Pharmaceuticals, J.H. Oortweg 19, 2333 CH, Leiden, The Netherlands. LA - eng PT - Editorial PT - Review DEP - 20170524 PL - England TA - Genome Med JT - Genome medicine JID - 101475844 RN - 0 (Histocompatibility Antigens Class I) SB - IM MH - *Histocompatibility Antigens Class I MH - Humans MH - *Immunologic Surveillance MH - Immunotherapy MH - T-Lymphocytes/immunology/*metabolism PMC - PMC5442872 EDAT- 2017/05/26 06:00 MHDA- 2017/09/02 06:00 PMCR- 2017/05/24 CRDT- 2017/05/26 06:00 PHST- 2017/05/26 06:00 [entrez] PHST- 2017/05/26 06:00 [pubmed] PHST- 2017/09/02 06:00 [medline] PHST- 2017/05/24 00:00 [pmc-release] AID - 10.1186/s13073-017-0439-8 [pii] AID - 439 [pii] AID - 10.1186/s13073-017-0439-8 [doi] PST - epublish SO - Genome Med. 2017 May 24;9(1):44. doi: 10.1186/s13073-017-0439-8.