PMID- 28539287
OWN - NLM
STAT- MEDLINE
DCOM- 20181119
LR  - 20200612
IS  - 1673-4254 (Print)
IS  - 2663-0842 (Electronic)
IS  - 1673-4254 (Linking)
VI  - 37
IP  - 5
DP  - 2017 May 20
TI  - [Calculation of orbital fat volumes for determining treatment timing for thyroid- 
      associated ophthalmopathy].
PG  - 640-645
AB  - OBJECTIVE: To analyze the relationship between orbital fat volume and the 
      progression and prognosis of thyroid- associated ophthalmopathy (TAO) and 
      determine the optimal treatment timing for TAO. METHODS: The clinical data were 
      collected from 35 patients (70 orbits) with a definite diagnosis of TAO between 
      January, 2016 and December, 2016. The correlation between orbital fat volume and 
      the clinical parameters was evaluated. We also analyzed the correlation of the 
      signal intensity ratio (SIR) of the extraocular muscles with the clinical 
      parameters. The orbital fat volume was compared between patients with TAO and 12 
      control subjects. RESULTS: The orbital fat volume was significantly correlated 
      with the duration of TAO (r=0.480, P<0.01), but showed no significant difference 
      between patients with a disease course within 6 months and those with a disease 
      course of 6 to 12 months (P=0.084). The patients with a disease course beyond 12 
      months had a significantly greater orbital fat volume than those with a disease 
      course of 6 months (P<0.01) or 6 to 12 months (P<0.05). The orbital fat volume 
      was correlated with the degree of proptosis (r=0.622, P<0.01), and an increase of 
      exophthalmos by 1 mm was associated with a total orbital volume increment of 0.88 
      mL. The clinical activity score was correlated with the SIR of the extraorbital 
      muscles (r=0.536, P<0.01) and levels of anti-thyroid-stimulating hormone receptor 
      antibody (r=0.416,P<0.01). The orbital fat volume was significantly greater in 
      TAO patients than in the healthy individuals (P<0.01). CONCLUSION: In patients 
      with TAO, the peak increase of orbital fat volume occurs one year after the 
      disease onset. Measurement of the orbital fat volume combined with SIR of the 
      extraorbital muscles can serve as an indicator for determining the optimal timing 
      for intervention of TAO and helps in the evaluation of prognosis of the patients.
FAU - Jiang, Wei
AU  - Jiang W
AD  - Department of Endocrinology, Third Affiliated Hospital of Southern Medical 
      University, Guangzhou 510630, China.E-mail: 527705916@qq.com.
FAU - Cai, Qiu-Yue
AU  - Cai QY
FAU - Li, Zhang-Fang
AU  - Li ZF
FAU - Chen, Zhi-Yi
AU  - Chen ZY
FAU - Luo, Yao-Sheng
AU  - Luo YS
FAU - Hu, Shi-di
AU  - Hu SD
FAU - Shen, Jie
AU  - Shen J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
SB  - IM
MH  - Adipose Tissue/*anatomy & histology
MH  - Exophthalmos
MH  - Eye
MH  - Graves Ophthalmopathy/*therapy
MH  - Humans
MH  - Orbit/*anatomy & histology
PMC - PMC6780468
EDAT- 2017/05/26 06:00
MHDA- 2018/11/20 06:00
PMCR- 2017/05/20
CRDT- 2017/05/26 06:00
PHST- 2017/05/26 06:00 [entrez]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2018/11/20 06:00 [medline]
PHST- 2017/05/20 00:00 [pmc-release]
AID - nfykdxxb-37-5-640 [pii]
AID - 10.3969/j.issn.1673-4254.2017.05.12 [doi]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2017 May 20;37(5):640-645. doi: 
      10.3969/j.issn.1673-4254.2017.05.12.