PMID- 28542109
OWN - NLM
STAT- MEDLINE
DCOM- 20180119
LR  - 20190329
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Print)
IS  - 1087-2418 (Linking)
VI  - 22
IP  - 4
DP  - 2017 Aug
TI  - Application and interpretation of histocompatibility data in pediatric kidney 
      transplantation.
PG  - 426-432
LID - 10.1097/MOT.0000000000000425 [doi]
AB  - PURPOSE OF REVIEW: Advances in technology to assess immunologic risk in solid 
      organ transplant offer an opportunity to optimize the approach to pediatric 
      deceased donor kidney transplant in the setting of a new allocation system in the 
      United States. RECENT FINDINGS: Degree of human leukocyte antigen (HLA) mismatch, 
      class II HLA mismatch, unacceptable antigens and donor-specific antibody (DSA) 
      detected by solid-phase assays, and epitope matching pretransplant affect 
      pediatric kidney transplant outcomes. Detection of de novo DSAs (dnDSAs) 
      posttransplant has been associated with increased risk of acute rejection and 
      worse allograft function. Development of dnDSA occurs in recipients with greater 
      epitope mismatching. SUMMARY: Improved long-term outcomes may be anticipated in 
      pediatric kidney transplant recipients by incorporating extended HLA mismatch 
      information and updating the clinical approach to donor kidney matching using 
      available technology to identify clinically relevant immunologic risk.
FAU - Fernandez, Hilda E
AU  - Fernandez HE
AD  - Division of Nephrology, Department of Medicine, Columbia University Medical 
      Center, New York, New York, USA.
LA  - eng
GR  - R01 MD009223/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies/*immunology
MH  - Child
MH  - HLA Antigens/*immunology
MH  - Histocompatibility/*immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Kidney Transplantation/*methods/mortality
PMC - PMC5570535
MID - NIHMS896321
COIS- Conflicts of Interest None.
EDAT- 2017/05/26 06:00
MHDA- 2018/01/20 06:00
PMCR- 2018/08/01
CRDT- 2017/05/26 06:00
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2018/01/20 06:00 [medline]
PHST- 2017/05/26 06:00 [entrez]
PHST- 2018/08/01 00:00 [pmc-release]
AID - 10.1097/MOT.0000000000000425 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2017 Aug;22(4):426-432. doi: 
      10.1097/MOT.0000000000000425.