PMID- 28542472 OWN - NLM STAT- MEDLINE DCOM- 20170912 LR - 20190208 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 12 IP - 5 DP - 2017 TI - The population impact of obesity, sedentary lifestyle, and tobacco and alcohol consumption on the prevalence of type 2 diabetes: Analysis of a health population survey in Chile, 2010. PG - e0178092 LID - 10.1371/journal.pone.0178092 [doi] LID - e0178092 AB - AIM: To estimate the impact of tobacco use, sedentary lifestyle, obesity and alcohol consumption on type 2 diabetes mellitus (T2DM) prevalence in the Chilean population. METHODS: The study-included 5,293 subjects with fasting glycaemia levels from the nationwide cross-sectional health survey in 2010, commissioned by the Ministry of Health, Chile. Crude and Adjusted Odds Ratio to T2DM and its corresponding 95% confidence interval were estimated through logistic regressions. Attributable fractions and population attributable fractions were estimated. RESULTS: T2DM prevalence was 9.5%. Sedentary lifestyles and obesity were significant risk factors for T2DM. 52,4% of T2DM could be avoided if these individuals were not obese, and at a population level, 23% of T2DM could be preventable if obesity did not exist. A 64% of T2DM is explained by sedentariness, and if people would become active, a 62,2% of the cases of diabetes could be avoided. INTERPRETATION: About 79% of T2DM cases in Chile could be prevented with cost-effective strategies focused on preventing sedentary lifestyle and obesity. It's therefore urgent to implement evidence-based public health polices, aimed to decrease the prevalence of T2DM, by controlling its risk factors and consequently, reducing the complications from T2DM. FAU - Bertoglia, Maria P AU - Bertoglia MP AUID- ORCID: 0000-0003-3631-0732 AD - Public Health Nutrition Program, School of Public Health, University of Chile, Santiago, Chile. FAU - Gormaz, Juan G AU - Gormaz JG AD - Molecular and Clinical Pharmacology Program, Bio-Medical Sciences Institute, University of Chile, Santiago, Chile. FAU - Libuy, Matias AU - Libuy M AD - Public Health Nutrition Program, School of Public Health, University of Chile, Santiago, Chile. FAU - Sanhueza, Dergica AU - Sanhueza D AD - Public Health Nutrition Program, School of Public Health, University of Chile, Santiago, Chile. FAU - Gajardo, Abraham AU - Gajardo A AD - Public Health Nutrition Program, School of Public Health, University of Chile, Santiago, Chile. FAU - Srur, Andrea AU - Srur A AD - Noncommunicable Diseases Department. Ministry of Health, Santiago, Chile. FAU - Wallbaum, Magdalena AU - Wallbaum M AD - Noncommunicable Diseases Department. Ministry of Health, Santiago, Chile. FAU - Erazo, Marcia AU - Erazo M AUID- ORCID: 0000-0002-0766-9503 AD - Public Health Nutrition Program, School of Public Health, University of Chile, Santiago, Chile. LA - eng PT - Journal Article DEP - 20170525 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Alcohol Drinking/*adverse effects/epidemiology MH - Alcoholism/complications/epidemiology MH - Chile/epidemiology MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/epidemiology/*etiology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Obesity/*complications/etiology MH - Prevalence MH - Risk Factors MH - *Sedentary Behavior MH - Surveys and Questionnaires MH - Tobacco Use/*adverse effects/epidemiology PMC - PMC5444782 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2017/05/26 06:00 MHDA- 2017/09/13 06:00 PMCR- 2017/05/25 CRDT- 2017/05/26 06:00 PHST- 2016/11/09 00:00 [received] PHST- 2017/05/07 00:00 [accepted] PHST- 2017/05/26 06:00 [entrez] PHST- 2017/05/26 06:00 [pubmed] PHST- 2017/09/13 06:00 [medline] PHST- 2017/05/25 00:00 [pmc-release] AID - PONE-D-16-41384 [pii] AID - 10.1371/journal.pone.0178092 [doi] PST - epublish SO - PLoS One. 2017 May 25;12(5):e0178092. doi: 10.1371/journal.pone.0178092. eCollection 2017.