PMID- 28543714
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20171209
IS  - 1469-8749 (Electronic)
IS  - 0012-1622 (Linking)
VI  - 59
IP  - 8
DP  - 2017 Aug
TI  - Motor function domains in alternating hemiplegia of childhood.
PG  - 822-828
LID - 10.1111/dmcn.13443 [doi]
AB  - AIM: To characterize motor function profiles in alternating hemiplegia of 
      childhood, and to investigate interrelationships between these domains and with 
      age. METHOD: We studied a cohort of 23 patients (9 males, 14 females; mean age 9y 
      4mo, range 4mo-43y) who underwent standardized tests to assess gross motor, upper 
      extremity motor control, motor speech, and dysphagia functions. RESULTS: Gross 
      Motor Function Classification System (GMFCS), Gross Motor Function Measure-88 
      (GMFM-88), Manual Ability Classification System (MACS), and Revised Melbourne 
      Assessment (MA2) scales manifested predominantly mild impairments; motor speech, 
      moderate to severe; Modified Dysphagia Outcome and Severity Scale (M-DOSS), 
      mild-to moderate deficits. GMFCS correlated with GMFM-88 scores (Pearson's 
      correlation, p=0.002), MACS (p=0.038), and MA2 fluency (p=0.005) and accuracy 
      (p=0.038) scores. GMFCS did not correlate with motor speech (p=0.399), MA2 
      dexterity (p=0.247), range of motion (p=0.063), or M-DOSS (p=0.856). Motor speech 
      was more severely impaired than the GMFCS (p<0.013). There was no correlation 
      between any of the assessment tools and age (p=0.210-0.798). INTERPRETATION: Our 
      data establish a detailed profile of motor function in alternating hemiplegia of 
      childhood, argue against the presence of worse motor function in older patients, 
      identify tools helpful in evaluating this population, and identify oropharyngeal 
      function as the more severely affected domain, suggesting that brain areas 
      controlling this function are more affected than others.
CI  - (c) 2017 Mac Keith Press.
FAU - Masoud, Melanie
AU  - Masoud M
AD  - Duke University Health System, Duke University School of Medicine, Durham, NC, 
      USA.
FAU - Gordon, Kelly
AU  - Gordon K
AD  - Department of Speech Pathology and Audiology, Duke University Health System, 
      Durham, NC, USA.
FAU - Hall, Amanda
AU  - Hall A
AD  - Department of Physical and Occupational Therapy, Duke University Health System, 
      Durham, NC, USA.
FAU - Jasien, Joan
AU  - Jasien J
AD  - Division of Pediatric Neurology, Duke University Health System, Durham, NC, USA.
FAU - Lardinois, Kara
AU  - Lardinois K
AD  - Department of Physical and Occupational Therapy, Duke University Health System, 
      Durham, NC, USA.
FAU - Uchitel, Julie
AU  - Uchitel J
AUID- ORCID: 0000-0003-4568-5421
AD  - Division of Pediatric Neurology, Duke University Health System, Durham, NC, USA.
FAU - Mclean, Melissa
AU  - Mclean M
AD  - Division of Pediatric Neurology, Duke University Health System, Durham, NC, USA.
FAU - Prange, Lyndsey
AU  - Prange L
AD  - Division of Pediatric Neurology, Duke University Health System, Durham, NC, USA.
FAU - Wuchich, Jeffrey
AU  - Wuchich J
AD  - Cure AHC, Inc., Rolesville, NC, USA.
FAU - Mikati, Mohamad A
AU  - Mikati MA
AD  - Division of Pediatric Neurology, Duke University Health System, Durham, NC, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170525
PL  - England
TA  - Dev Med Child Neurol
JT  - Developmental medicine and child neurology
JID - 0006761
RN  - Alternating hemiplegia of childhood
SB  - IM
CIN - Dev Med Child Neurol. 2017 Aug;59(8):778-779. PMID: 28556907
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Deglutition Disorders/diagnosis/etiology/physiopathology
MH  - Female
MH  - *Hemiplegia/complications/diagnosis/physiopathology
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Movement Disorders/diagnosis/etiology/physiopathology
MH  - *Severity of Illness Index
MH  - *Speech Disorders/diagnosis/etiology/physiopathology
MH  - Young Adult
EDAT- 2017/05/26 06:00
MHDA- 2017/07/20 06:00
CRDT- 2017/05/26 06:00
PHST- 2017/03/03 00:00 [accepted]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
PHST- 2017/05/26 06:00 [entrez]
AID - 10.1111/dmcn.13443 [doi]
PST - ppublish
SO  - Dev Med Child Neurol. 2017 Aug;59(8):822-828. doi: 10.1111/dmcn.13443. Epub 2017 
      May 25.