PMID- 28543987
OWN - NLM
STAT- MEDLINE
DCOM- 20180420
LR  - 20220408
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 22
IP  - 7
DP  - 2017 Oct
TI  - Modified GAP index for prediction of acute exacerbation of idiopathic pulmonary 
      fibrosis in non-small cell lung cancer.
PG  - 1379-1385
LID - 10.1111/resp.13075 [doi]
AB  - BACKGROUND AND OBJECTIVE: Predicting the incidence rate of acute exacerbation 
      (AE) of idiopathic pulmonary fibrosis (IPF) and its prognosis in patients with 
      non-small cell lung cancer (NSCLC) and IPF is difficult. The aim was to study the 
      incidence of IPF-AE during the clinical course of the disease and its prognosis 
      in patients with both NSCLC and IPF. METHODS: In this retrospective study, we 
      compared the incidence rate of AE during the clinical course of the disease as 
      well as the 1-year survival rate and overall survival (OS) of patients with NSCLC 
      and IPF using a modified gender, age and physiology (mGAP) staging system based 
      on gender, age and percent predicted forced vital capacity. RESULTS: Of 43 
      patients with NSCLC and IPF included in the final analysis, 17 patients (40%; 95% 
      CI: 26-54%) experienced AE during the clinical course of the disease. One-year 
      survival and median OS were 41.9% (95% CI: 28-57%) and 9.4 months, respectively. 
      Further analysis showed that the incidence of IPF-AE gradually increased and that 
      the 1-year survival rate and median OS gradually decreased with increasing mGAP 
      index score and stage. CONCLUSION: Our study suggested that mGAP index score and 
      cancer stage may predict IPF-AE and its prognosis in patients with NSCLC and IPF.
CI  - (c) 2017 Asian Pacific Society of Respirology.
FAU - Kobayashi, Haruki
AU  - Kobayashi H
AUID- ORCID: 0000-0002-3386-8063
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Omori, Shota
AU  - Omori S
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Nakashima, Kazuhisa
AU  - Nakashima K
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Wakuda, Kazushige
AU  - Wakuda K
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Ono, Akira
AU  - Ono A
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Kenmotsu, Hirotsugu
AU  - Kenmotsu H
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Naito, Tateaki
AU  - Naito T
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Murakami, Haruyasu
AU  - Murakami H
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Endo, Masahiro
AU  - Endo M
AD  - Division of Diagnostic Radiology, Shizuoka Cancer Center, Shizuoka, Japan.
FAU - Takahashi, Toshiaki
AU  - Takahashi T
AD  - Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170523
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/mortality/*physiopathology
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/mortality/*physiopathology
MH  - Lung Neoplasms/mortality/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Vital Capacity/*physiology
OTO - NOTNLM
OT  - acute exacerbation
OT  - gender, age and physiology index
OT  - idiopathic pulmonary fibrosis
OT  - lung cancer
OT  - non-small cell lung cancer
EDAT- 2017/05/26 06:00
MHDA- 2018/04/21 06:00
CRDT- 2017/05/26 06:00
PHST- 2016/10/19 00:00 [received]
PHST- 2017/04/05 00:00 [revised]
PHST- 2017/04/05 00:00 [accepted]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2018/04/21 06:00 [medline]
PHST- 2017/05/26 06:00 [entrez]
AID - 10.1111/resp.13075 [doi]
PST - ppublish
SO  - Respirology. 2017 Oct;22(7):1379-1385. doi: 10.1111/resp.13075. Epub 2017 May 23.