PMID- 28544081
OWN - NLM
STAT- MEDLINE
DCOM- 20180710
LR  - 20181202
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 71
IP  - 6
DP  - 2017 Jun
TI  - Direct medical costs of severe hypoglycaemic events in patients with type 2 
      diabetes in England: A retrospective database study.
LID - 10.1111/ijcp.12958 [doi]
AB  - AIMS: Hypoglycaemia in patients with diabetes can be induced by insulins and 
      sulfonylureas. We assessed the real-world impact of specific monotherapy and 
      combination regimens on hypoglycaemic events requiring hospitalisation and 
      related secondary costs to the English healthcare system. METHODS: This 
      retrospective observational study used the Clinical Practice Research Datalink 
      with linked hospital admission data during 2008-2012. Patients with type 2 
      diabetes mellitus (T2DM) using antihyperglycaemic agents (AHAs) were assigned to 
      mutually exclusive subgroups (insulin- and non-insulin-containing regimens; 
      treatment groups of interest; age group) based on treatment at index date (date 
      of first AHA prescription). Outcomes were number and cost of hospital admissions 
      with hypoglycaemic event-related diagnosis codes. RESULTS: We identified 110 206 
      patients with T2DM (mean age 64.9 years, time since diagnosis 5.4 years, HbA(1c) 
      at index 7.4%), with 439 hypoglycaemic events requiring inpatient hospitalisation 
      (mean length of stay 6.3 days, mean cost/stay  pound1351). Event rates and cost of 
      stay were highest in patients treated with sulfonylurea- or insulin-based 
      regimens. Event rates, duration and cost of stay were higher in older patients. 
      CONCLUSION: Rates of severe hypoglycaemic events varied substantially between 
      T2DM regimens. In this study of patients treated in clinical practice in England, 
      sulfonylurea- and insulin-based regimens were associated with the highest event 
      rates and costs associated with hospitalisation for severe hypoglycaemic events; 
      hospitalisation for severe hypoglycaemic events was not observed with dipeptidyl 
      peptidase-4 inhibitor monotherapy or with metformin.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Holbrook, Tim
AU  - Holbrook T
AD  - Adelphi Real World, Manchester, UK.
FAU - Tang, Yuexin
AU  - Tang Y
AUID- ORCID: 0000-0001-6528-4145
AD  - MRL, Merck & Co., Inc., Kenilworth, NJ, USA.
FAU - Das, Romita
AU  - Das R
AD  - HTA and Observational Research, MSD Ltd, Hoddesdon, UK.
FAU - Shankar, R Ravi
AU  - Shankar RR
AD  - MRL, Merck & Co., Inc., Kenilworth, NJ, USA.
FAU - Tunceli, Kaan
AU  - Tunceli K
AD  - MRL, Merck & Co., Inc., Kenilworth, NJ, USA.
FAU - Williams, Jean
AU  - Williams J
AD  - MRL, Merck & Co., Inc., Kenilworth, NJ, USA.
FAU - Radican, Larry
AU  - Radican L
AD  - MRL, Merck & Co., Inc., Kenilworth, NJ, USA.
FAU - Holden, Sarah E
AU  - Holden SE
AD  - Pharmatelligence, Cardiff, UK.
FAU - Morgan, Chris Ll
AU  - Morgan CL
AD  - Pharmatelligence, Cardiff, UK.
FAU - Piercy, James
AU  - Piercy J
AD  - Adelphi Real World, Manchester, UK.
FAU - Currie, Craig J
AU  - Currie CJ
AD  - Pharmatelligence, Cardiff, UK.
AD  - Cardiff University, Cardiff, UK.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170523
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Sulfonylurea Compounds)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/complications/drug therapy/*economics
MH  - England
MH  - Female
MH  - *Health Care Costs
MH  - Hospitalization/economics
MH  - Humans
MH  - Hypoglycemia/chemically induced/drug therapy/*economics
MH  - Hypoglycemic Agents/economics/therapeutic use
MH  - Insulin/economics/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sulfonylurea Compounds/economics/therapeutic use
EDAT- 2017/05/26 06:00
MHDA- 2018/07/11 06:00
CRDT- 2017/05/26 06:00
PHST- 2016/12/15 00:00 [received]
PHST- 2017/03/25 00:00 [accepted]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2018/07/11 06:00 [medline]
PHST- 2017/05/26 06:00 [entrez]
AID - 10.1111/ijcp.12958 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2017 Jun;71(6). doi: 10.1111/ijcp.12958. Epub 2017 May 23.