PMID- 28544509
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20180402
IS  - 1521-2254 (Electronic)
IS  - 1099-498X (Linking)
VI  - 19
IP  - 6-7
DP  - 2017 Jun
TI  - Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic 
      retinopathy.
LID - 10.1002/jgm.2960 [doi]
AB  - BACKGROUND: Little is known about the contribution of ARHGAP22 polymorphism to 
      diabetic retinopathy (DR) risk. We performed a case-control study to investigate 
      the associations between ARHGAP22 and the risk of DR in a Chinese Han population. 
      METHODS: A total of 341 patients with type 2 diabetes mellitus (T2DM) were 
      selected. All patients underwent a complete eye examination. Based on this, the 
      patients with T2DM were divided into two subgroups: 188 patients with DR and 153 
      patients without DR. Five single nucleotide polymorphism (SNPs) were selected and 
      genotyped using the MassARRAY method (Sequenom, San Diego, CA, USA). The odds 
      ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional 
      logistic regression adjusted for age and sex. RESULTS: Two susceptibility SNPs in 
      ARHGAP22 were found to be associated with an increased risk of DR both before and 
      after the adjustment: rs10491034 under the dominant model (adjusted OR = 0.51, 
      95% CI = 0.27-0.95, p = 0.032) and additive model (adjusted OR = 0.47, 95% 
      CI = 0.26-0.84, p = 0.0098) and rs3844492 under the codominant model (adjusted 
      OR = 3.14, 95% CI = 1.10-9.01, p = 0.023) and recessive model (adjusted 
      OR = 3.52, 95% CI = 1.26-9.85, p = 0.011). CONCLUSIONS: Our findings reveal a 
      significant association between SNPs in the ARHGAP22 gene and DR risk in a Han 
      Chinese population.
CI  - Copyright (c) 2017 John Wiley & Sons, Ltd.
FAU - Li, Rong
AU  - Li R
AD  - School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
AD  - Department of Ophthalmology, the First Affiliated Hospital of Xi'an Medical 
      University, Xi'an, Shaanxi, China.
FAU - Chen, Peng
AU  - Chen P
AD  - Institution of Basic Medical Science, Xi'an Medical University, Xi'an, Shaanxi, 
      China.
FAU - Li, Jing
AU  - Li J
AD  - School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
FAU - Yan, Mengdan
AU  - Yan M
AD  - School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
FAU - Li, Jingjie
AU  - Li J
AD  - School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
FAU - Li, Shanqu
AU  - Li S
AD  - Medical Examination Center of Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an, China.
FAU - Zhu, Hongli
AU  - Zhu H
AD  - School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Gene Med
JT  - The journal of gene medicine
JID - 9815764
RN  - 0 (ARHGAP22 protein, human)
RN  - 0 (GTPase-Activating Proteins)
SB  - IM
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*complications/genetics/physiopathology
MH  - Diabetic Retinopathy/*etiology/*genetics/physiopathology
MH  - Female
MH  - GTPase-Activating Proteins/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - ARHGAP22
OT  - diabetic retinopathy
OT  - gene polymorphisms
EDAT- 2017/05/26 06:00
MHDA- 2018/04/03 06:00
CRDT- 2017/05/26 06:00
PHST- 2017/02/20 00:00 [received]
PHST- 2017/05/04 00:00 [revised]
PHST- 2017/05/08 00:00 [accepted]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
PHST- 2017/05/26 06:00 [entrez]
AID - 10.1002/jgm.2960 [doi]
PST - ppublish
SO  - J Gene Med. 2017 Jun;19(6-7). doi: 10.1002/jgm.2960.