PMID- 28544629
OWN - NLM
STAT- MEDLINE
DCOM- 20180406
LR  - 20180424
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 7
IP  - 7
DP  - 2017 Jul
TI  - Household pet exposure, allergic sensitization, and rhinitis in the U.S. 
      population.
PG  - 645-651
LID - 10.1002/alr.21929 [doi]
AB  - BACKGROUND: The effect of animal dander exposure on allergic sensitization may be 
      age-dependent. A comparison between the association of the levels of exposure to 
      pet allergen with rhinitis symptoms and allergic sensitization in children and 
      adults is yet to be performed in the U.S. METHODS: Cross-sectional study of 3034 
      adults (age, 20 to 85 years) and 2104 children (age, 6 to 19 years) in the 
      National Health and Nutrition Examination Survey, 2005-2006. Samples of household 
      dust were collected to measure the amounts of indoor allergens in the 
      participants' homes. Self-reported rhinitis was based on symptoms during the past 
      12 months, and allergen sensitization was defined as a positive response to any 
      of the 19 specific immunoglobulin E (IgE) antigens tested. RESULTS: Higher levels 
      of exposure to dog dander were associated with a higher prevalence of any 
      allergic sensitization in adults (prevalence ratio [PR] 1.19; 95% confidence 
      interval [CI], 1.01 to 1.39), but a lower prevalence in children (PR 0.84; 95% 
      CI, 0.73 to 0.096), p-interaction by age group 0.02. Cat exposure was associated 
      with an increased prevalence of rhinitis symptoms in adults (PR for the 3rd vs 
      lowest tertile of cat dander concentrations: 1.14; 95% CI, 1.05 to 1.23) but not 
      in children (PR for the 3rd vs lowest tertile of cat dander IgE concentrations: 
      0.86; 95% CI, 0.70 to 1.07), p-interaction 0.01. CONCLUSION: Allergic 
      sensitization and symptomatic response to pet dander exposure may vary based on 
      age. Further studies are necessary to assess the mechanisms for these apparent 
      differences.
CI  - (c) 2017 ARS-AAOA, LLC.
FAU - Shargorodsky, Josef
AU  - Shargorodsky J
AD  - Coastal Ear Nose and Throat, Neptune, NJ.
FAU - Garcia-Esquinas, Esther
AU  - Garcia-Esquinas E
AD  - Department of Preventive Medicine and Public Health, School of Medicine, 
      Universidad Autonoma de Madrid, Spain.
AD  - Instituto de Investigacion Hospital Universitario La Paz (IdiPaz) and Centro de 
      Investigacion Biomedica en Red (CIBER) of Epidemiology and Public Health 
      (CIBERESP), Madrid, Spain.
FAU - Umanskiy, Rachel
AU  - Umanskiy R
AD  - Oakland University, Rochester, MI.
FAU - Navas-Acien, Ana
AU  - Navas-Acien A
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, NY.
FAU - Lin, Sandra Y
AU  - Lin SY
AD  - Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University 
      School of Medicine, Baltimore, MD.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170525
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Allergens/immunology
MH  - Animals
MH  - Cats
MH  - Child
MH  - Cross-Sectional Studies
MH  - Dander/immunology
MH  - Dogs
MH  - Humans
MH  - Immunization
MH  - Immunoglobulin E/metabolism
MH  - Middle Aged
MH  - Pets/*immunology
MH  - Rhinitis, Allergic/*epidemiology
MH  - United States/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - allergic sensitization
OT  - allergy
OT  - household dust
OT  - pets
OT  - rhinitis
EDAT- 2017/05/26 06:00
MHDA- 2018/04/07 06:00
CRDT- 2017/05/26 06:00
PHST- 2016/11/03 00:00 [received]
PHST- 2017/01/18 00:00 [revised]
PHST- 2017/01/31 00:00 [accepted]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2018/04/07 06:00 [medline]
PHST- 2017/05/26 06:00 [entrez]
AID - 10.1002/alr.21929 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2017 Jul;7(7):645-651. doi: 10.1002/alr.21929. Epub 
      2017 May 25.