PMID- 28544644 OWN - NLM STAT- MEDLINE DCOM- 20180814 LR - 20181217 IS - 1753-0407 (Electronic) IS - 1753-0407 (Linking) VI - 10 IP - 2 DP - 2018 Feb TI - beta-Cell function in postmenopausal women with isolated post-challenge hyperglycemia. PG - 158-165 LID - 10.1111/1753-0407.12571 [doi] AB - BACKGROUND: Isolated post-challenge hyperglycemia (IPH) is an early stage of type 2 diabetes mellitus (T2DM), with fasting glucose <126 mg/dL and 2-h glucose >/=200 mg/dL. Observations of insulin secretion profile in subjects with IPH may provide an insight into the pathogenesis of T2DM in older women. METHODS: We recruited 555 naturally postmenopausal women without a history of T2DM to the present study. All participants received a 75-g oral glucose tolerance test to determine whether they had IPH. General linear models were used to compare differences in glucose metabolism among subjects. RESULTS: Early phase insulin responses to oral glucose were significantly decreased in women with IPH versus those with impaired glucose tolerance (IGT) and normal glucose tolerance (geometric mean [95% confidence interval] insulinogenic index 61 [54-79] vs 90 [83-97] and 105 [96-116], respectively; P < 0.0001). In addition, there were significant decreases in late-phase insulin release as metabolic status shifted from normal glucose tolerance to IGT to IPH. In the present cohort, the relative contribution of early insulin secretion to 2-h glucose was no longer significant ( P = 0.15) after multiple factors, including indicators of insulin resistance and late-phase insulin release, were entered into the regression model simultaneously. CONCLUSIONS: The results demonstrate that postmenopausal women with IPH are characterized by impaired beta-cell function. There were significant decreases in early and late-phase insulin release as glucose intolerance escalated. Disturbance in beta-cell function seems to be an important factor associated with early T2DM in postmenopausal women. CI - (c) 2017 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd. FAU - Hwu, Chii-Min AU - Hwu CM AUID- ORCID: 0000-0002-8209-9627 AD - Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. AD - Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan. FAU - Lin, Yi-Chun AU - Lin YC AD - Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. AD - Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan. FAU - Lin, Kuan-Hung AU - Lin KH AD - Institute of Public Health, National Yang-Ming University, Taipei, Taiwan. AD - Department of Medicine, National Yang-Ming University Hospital, Yi-Lan, Taiwan. LA - eng PT - Journal Article DEP - 20170714 PL - Australia TA - J Diabetes JT - Journal of diabetes JID - 101504326 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Insulin) SB - IM MH - Biomarkers/analysis MH - Blood Glucose/analysis MH - Diabetes Mellitus, Type 2/*diagnosis/metabolism MH - Fasting MH - Female MH - Follow-Up Studies MH - Glucose Intolerance/*diagnosis/metabolism MH - Glucose Tolerance Test MH - Humans MH - Hyperglycemia/*physiopathology MH - Insulin/*metabolism MH - Insulin Resistance MH - Insulin Secretion MH - Insulin-Secreting Cells/*metabolism MH - Middle Aged MH - *Postmenopause MH - Prognosis OTO - NOTNLM OT - diabetes mellitus OT - insulin OT - postmenopause OT - postprandial hyperglycemia OT - 糖尿病 OT - 绝经后 OT - 胰岛素 OT - 餐后高血糖 EDAT- 2017/05/26 06:00 MHDA- 2018/08/15 06:00 CRDT- 2017/05/26 06:00 PHST- 2016/08/26 00:00 [received] PHST- 2017/04/12 00:00 [revised] PHST- 2017/05/02 00:00 [accepted] PHST- 2017/05/26 06:00 [pubmed] PHST- 2018/08/15 06:00 [medline] PHST- 2017/05/26 06:00 [entrez] AID - 10.1111/1753-0407.12571 [doi] PST - ppublish SO - J Diabetes. 2018 Feb;10(2):158-165. doi: 10.1111/1753-0407.12571. Epub 2017 Jul 14.