PMID- 28544801
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20190206
IS  - 1939-0041 (Electronic)
IS  - 1939-5116 (Print)
IS  - 1939-0041 (Linking)
VI  - 10
IP  - 1
DP  - 2018 Jan
TI  - Nanotherapeutic systems for local treatment of brain tumors.
LID - 10.1002/wnan.1479 [doi]
AB  - Malignant brain tumor, including the most common type glioblastoma, are 
      histologically heterogeneous and invasive tumors known as the most devastating 
      neoplasms with high morbidity and mortality. Despite multimodal treatment 
      including surgery, radiotherapy, chemotherapy, and immunotherapy, the disease 
      inevitably recurs and is fatal. This lack of curative options has motivated 
      researchers to explore new treatment strategies and to develop new drug delivery 
      systems (DDSs); however, the unique anatomical, physiological, and pathological 
      features of brain tumors greatly limit the effectiveness of conventional 
      chemotherapy. In this context, we review the recent progress in the development 
      of nanoparticle-based DDSs aiming to address the key challenges in transporting 
      sufficient amount of therapeutic agents into the brain tumor areas while 
      minimizing the potential side effects. We first provide an overview of the 
      standard treatments currently used in the clinic for the management of brain 
      cancers, discussing the effectiveness and limitations of each therapy. We then 
      provide an in-depth review of nanotherapeutic systems that are intended to bypass 
      the blood-brain barrier, overcome multidrug resistance, infiltrate larger 
      tumorous tissue areas, and/or release therapeutic agents in a controlled manner. 
      WIREs Nanomed Nanobiotechnol 2018, 10:e1479. doi: 10.1002/wnan.1479 This article 
      is categorized under: Implantable Materials and Surgical Technologies > 
      Nanomaterials and Implants Therapeutic Approaches and Drug Discovery > 
      Nanomedicine for Oncologic Disease.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Chakroun, Rami Walid
AU  - Chakroun RW
AD  - Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 
      Baltimore, MD, USA.
FAU - Zhang, Pengcheng
AU  - Zhang P
AD  - Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 
      Baltimore, MD, USA.
FAU - Lin, Ran
AU  - Lin R
AD  - Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 
      Baltimore, MD, USA.
FAU - Schiapparelli, Paula
AU  - Schiapparelli P
AD  - Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
FAU - Quinones-Hinojosa, Alfredo
AU  - Quinones-Hinojosa A
AD  - Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
FAU - Cui, Honggang
AU  - Cui H
AD  - Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 
      Baltimore, MD, USA.
LA  - eng
GR  - R21 CA191740/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170524
PL  - United States
TA  - Wiley Interdiscip Rev Nanomed Nanobiotechnol
JT  - Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
JID - 101508311
RN  - 0 (Hydrogels)
SB  - IM
MH  - Brain Neoplasms/*therapy
MH  - Convection
MH  - Drug Delivery Systems
MH  - Humans
MH  - Hydrogels/chemistry
MH  - Nanomedicine/*methods
PMC - PMC5701865
MID - NIHMS877967
EDAT- 2017/05/26 06:00
MHDA- 2018/07/24 06:00
PMCR- 2019/01/01
CRDT- 2017/05/26 06:00
PHST- 2016/06/30 00:00 [received]
PHST- 2017/04/14 00:00 [revised]
PHST- 2017/04/18 00:00 [accepted]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2017/05/26 06:00 [entrez]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.1002/wnan.1479 [doi]
PST - ppublish
SO  - Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 Jan;10(1):10.1002/wnan.1479. 
      doi: 10.1002/wnan.1479. Epub 2017 May 24.