PMID- 28544856
OWN - NLM
STAT- MEDLINE
DCOM- 20180201
LR  - 20181202
IS  - 1747-6356 (Electronic)
IS  - 1747-6348 (Linking)
VI  - 11
IP  - 7
DP  - 2017 Jul
TI  - Recent advances in connective tissue disease related interstitial lung disease.
PG  - 591-603
LID - 10.1080/17476348.2017.1335600 [doi]
AB  - Interstitial lung disease (ILD) is a common manifestation of connective tissue 
      disease (CTD). Although the majority of patients with CTD-ILD are stable or 
      slowly progressive, a significant group exhibits a more severe and progressive 
      decline. Interstitial pneumonia with autoimmune features (IPAF) describes the 
      subset of patients with interstitial pneumonia who have features suggesting 
      underlying autoimmunity, but whose features fall short of a clear diagnosis of 
      CTD. Areas covered: In this focused review, we discuss recent advances in early 
      detection, prognostic evaluation, and management of autoimmune forms of ILD. 
      Expert commentary: Early detection of ILD and a better understanding of factors 
      that impact prognostication may be helpful when making decisions regarding 
      therapeutic interventions. The treatment of CTD-ILD should be comprehensive, is 
      often fraught with challenges and can be complicated by comorbid conditions and 
      extra-thoracic disease activities. Several large randomized studies have examined 
      the impact of immunosuppressive therapy for CTD-ILD, however, additional studies 
      are needed to determine the optimal treatment strategies. Future studies may 
      provide additional information about the best treatments in patients with IPAF.
FAU - Suzuki, Atsushi
AU  - Suzuki A
AD  - a Department of Respiratory Medicine and Allergy , Tosei General Hospital , Seto 
      , Japan.
FAU - Kondoh, Yasuhiro
AU  - Kondoh Y
AD  - a Department of Respiratory Medicine and Allergy , Tosei General Hospital , Seto 
      , Japan.
FAU - Fischer, Aryeh
AU  - Fischer A
AD  - b Department of Medicine, Divisions of Rheumatology, Pulmonary Sciences and 
      Critical Care Medicine , University of Colorado , Aurora , CO , USA.
LA  - eng
PT  - Journal Article
DEP - 20170602
PL  - England
TA  - Expert Rev Respir Med
JT  - Expert review of respiratory medicine
JID - 101278196
SB  - IM
MH  - Connective Tissue Diseases/*physiopathology
MH  - Humans
MH  - *Lung Diseases, Interstitial/diagnosis
MH  - Prognosis
OTO - NOTNLM
OT  - CTD-ILD
OT  - Connective tissue disease
OT  - interstitial lung disease
OT  - interstitial pneumonia with autoimmune features
OT  - recent advances
EDAT- 2017/05/26 06:00
MHDA- 2018/02/02 06:00
CRDT- 2017/05/26 06:00
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2018/02/02 06:00 [medline]
PHST- 2017/05/26 06:00 [entrez]
AID - 10.1080/17476348.2017.1335600 [doi]
PST - ppublish
SO  - Expert Rev Respir Med. 2017 Jul;11(7):591-603. doi: 
      10.1080/17476348.2017.1335600. Epub 2017 Jun 2.