PMID- 28545121
OWN - NLM
STAT- MEDLINE
DCOM- 20170919
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 5
DP  - 2017
TI  - Measurement of macular structure-function relationships using spectral 
      domain-optical coherence tomography (SD-OCT) and pattern electroretinograms 
      (PERG).
PG  - e0178004
LID - 10.1371/journal.pone.0178004 [doi]
LID - e0178004
AB  - BACKGROUND: Retinal ganglion cell (RGC) death is a common cause of loss of vision 
      during glaucoma. Pattern electroretinogram (PERG) is an objective measure of the 
      central retinal function that correlates with macular GCL thickness. The aim of 
      this study is to determine possible relationships between the N95 amplitude of 
      pattern electroretinogram (PERGamp) and macular ganglion cell/inner plexiform 
      layer thickness (GCIPLT). METHODS AND FINDINGS: This was a retrospective and 
      comparative study including 74 glaucoma patients (44 early stage and 30 advanced 
      stage cases) and 66 normal control subjects. Macular GCIPLT was measured using 
      Cirrus spectral domain-optical coherence tomography. Standard automated perimetry 
      and pattern ERGs were used in all patient examinations. Three types of regression 
      analysis (broken stick, linear regression, and quadratic regression) were used to 
      evaluate possible relationships between PERGamp and GCIPLT. Correlations between 
      visual field parameters and GCIPLT were evaluated according to glaucoma severity. 
      The best fit model for the relationship between PERGamp and GCIPLT was the linear 
      regression model (r2 = 0.22; P < 0.001). The best-fit model for the relationship 
      between visual field parameters and GCIPLT was the broken stick model. During 
      early glaucoma, macular GCIPLT was positively correlated with PERGamp, but not 
      with visual field loss. In advanced glaucoma, macular GCIPLT was positively 
      correlated with both PERGamp and visual field loss. CONCLUSIONS: PERGamp was 
      significantly correlated with macular GCIPT in early glaucoma patients, while 
      visual field performance showed no correlation with GCIPLT. PERGamp can therefore 
      assist clinicians in making an early decision regarding the most suitable 
      treatment plan, especially when GCIPLT is thinning with no change in visual field 
      performance.
FAU - Park, Keunheung
AU  - Park K
AD  - Department of Ophthalmology, Pusan National University College of Medicine, 
      Busan, Korea.
FAU - Kim, Jinmi
AU  - Kim J
AD  - Department of Biostatistics, Clinical Trial Center, Biomedical Research 
      Institute, Pusan National University Hospital, Busan, Korea.
FAU - Lee, Jiwoong
AU  - Lee J
AUID- ORCID: 0000-0002-1053-612X
AD  - Department of Ophthalmology, Pusan National University College of Medicine, 
      Busan, Korea.
AD  - Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20170517
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
EIN - PLoS One. 2017 Jul 10;12 (7):e0181390. PMID: 28700703
MH  - Adult
MH  - Aged
MH  - Electroretinography
MH  - Female
MH  - Glaucoma/*diagnostic imaging/pathology
MH  - Humans
MH  - Macula Lutea/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
PMC - PMC5435332
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/05/26 06:00
MHDA- 2017/09/20 06:00
PMCR- 2017/05/17
CRDT- 2017/05/26 06:00
PHST- 2017/03/20 00:00 [received]
PHST- 2017/05/06 00:00 [accepted]
PHST- 2017/05/26 06:00 [entrez]
PHST- 2017/05/26 06:00 [pubmed]
PHST- 2017/09/20 06:00 [medline]
PHST- 2017/05/17 00:00 [pmc-release]
AID - PONE-D-17-10916 [pii]
AID - 10.1371/journal.pone.0178004 [doi]
PST - epublish
SO  - PLoS One. 2017 May 17;12(5):e0178004. doi: 10.1371/journal.pone.0178004. 
      eCollection 2017.